Impact of resveratrol on glucose control, hippocampal structure and connectivity, and memory performance in patients with mild cognitive impairment

  • In healthy older adults, resveratrol supplementation has been shown to improve long-term glucose control, resting-state functional connectivity (RSFC) of the hippocampus, and memory function. Here, we aimed to investigate if these beneficial effects extend to individuals at high-risk for dementia, i.e., patients with mild cognitive impairment (MCI). In a randomized, double-blind interventional study, 40 well-characterized patients with MCI (21 females; 50–80 years) completed 26 weeks of resveratrol (200 mg/d; n = 18) or placebo (1,015 mg/d olive oil; n = 22) intake. Serum levels of glucose, glycated hemoglobin A1c and insulin were determined before and after intervention. Moreover, cerebral magnetic resonance imaging (MRI) (3T) (n = 14 vs. 16) was conducted to analyze hippocampus volume, microstructure and RSFC, and neuropsychological testing was conducted to assess learning and memory (primary endpoint) at both time points. In comparison to the control group, resveratrol supplementation resulted in lower glycated hemoglobin A1c concentration with a moderate effect size (ANOVARM p = 0.059, Cohen's d = 0.66), higher RSFC between right anterior hippocampus and right angular cortex (p < 0.001), and led to a moderate preservation of left anterior hippocampus volume (ANOVARM p = 0.061, Cohen's d = 0.68). No significant differences in memory performance emerged between groups. This proof-of-concept study indicates for the first-time that resveratrol intake may reduce glycated hemoglobin A1c, preserves hippocampus volume, and improves hippocampus RSFC in at-risk patients for dementia. Larger trials with longer intervention time should now determine if these benefits can be validated and extended to cognitive function.

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Author:Theresa Köbe, A. Veronica WitteORCiDGND, Ariane Schnelle, Valentina Tesky, Johannes PantelORCiDGND, Jan-Philipp Schuchardt, Andreas Hahn, Jens Bohlken, Ulrike Grittner, Agnes Flöel
URN:urn:nbn:de:hebis:30:3-431768
URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339301
DOI:https://doi.org/10.3389/fnins.2017.00105
ISSN:1662-453X
ISSN:1662-4548
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/28326010
Parent Title (English):Frontiers in neuroscience
Publisher:Frontiers Research Foundation
Place of publication:Lausanne
Contributor(s):Renaud La Joie
Document Type:Article
Language:English
Date of Publication (online):2017/04/03
Date of first Publication:2017/03/07
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2017/04/03
Tag:MCI; hippocampus; memory performance; resting-state functional connectivity; resveratrol
Volume:11
Issue:Art. 105
Page Number:11
First Page:1
Last Page:11
Note:
Copyright © 2017 Köbe, Witte, Schnelle, Tesky, Pantel, Schuchardt, Hahn, Bohlken, Grittner and Flöel. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
HeBIS-PPN:425295877
Institutes:Medizin / Medizin
Angeschlossene und kooperierende Institutionen / Universität des 3. Lebensalters e.V.
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0