The role of the melatoninergic system in light-entrained behavior of mice
- The role of endogenous melatonin for the control of the circadian system under entrained conditions and for the determination of the chronotype is still poorly understood. Mice with deletions in the melatoninergic system (melatonin deficiency or the lack of melatonin receptors, respectively) do not display any obvious defects in either their spontaneous (circadian) or entrained (diurnal) rhythmic behavior. However, there are effects that can be detected by analyzing the periodicity of the locomotor behaviors in some detail. We found that melatonin-deficient mice (C57Bl), as well as melatonin-proficient C3H mice that lack the melatonin receptors (MT) 1 and 2 (C3H MT1,2 KO), reproduce their diurnal locomotor rhythms with significantly less accuracy than mice with an intact melatoninergic system. However, their respective chronotypes remained unaltered. These results show that one function of the endogenous melatoninergic system might be to stabilize internal rhythms under conditions of a steady entrainment, while it has no effects on the chronotype.
Author: | Martina Pfeffer, Horst-Werner KorfORCiDGND, Helmut Wicht |
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URN: | urn:nbn:de:hebis:30:3-440036 |
DOI: | https://doi.org/10.3390/ijms18030530 |
ISSN: | 1422-0067 |
ISSN: | 1661-6596 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/28257037 |
Parent Title (English): | International journal of molecular sciences |
Publisher: | Molecular Diversity Preservation International |
Place of publication: | Basel |
Contributor(s): | Russel J. Reiter |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2017/04/25 |
Date of first Publication: | 2017/03/01 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2017/04/25 |
Tag: | chronotype; circadian; diurnal; locomotor rhythm; melatonin; stability |
Volume: | 18 |
Issue: | 3, Art. 530 |
Page Number: | 8 |
First Page: | 1 |
Last Page: | 8 |
Note: | © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
HeBIS-PPN: | 421370041 |
Institutes: | Medizin / Medizin |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - Namensnennung 4.0 |