Immunopathogenic mechanisms of autoimmune Hepatitis : how much do we know from animal models?
- Autoimmune hepatitis (AIH) is characterized by a progressive destruction of the liver parenchyma and a chronic fibrosis. The current treatment of autoimmune hepatitis is still largely dependent on the administration of corticosteroids and cytostatic drugs. For a long time the development of novel therapeutic strategies has been hampered by a lack of understanding the basic immunopathogenic mechanisms of AIH and the absence of valid animal models. However, in the past decade, knowledge from clinical observations in AIH patients and the development of innovative animal models have led to a situation where critical factors driving the disease have been identified and alternative treatments are being evaluated. Here we will review the insight on the immunopathogenesis of AIH as gained from clinical observation and from animal models.
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| Verfasserangaben: | Urs ChristenORCiDGND, Edith HintermannORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-441172 |
| DOI: | https://doi.org/10.3390/ijms17122007 |
| ISSN: | 1422-0067 |
| ISSN: | 1661-6596 |
| Pubmed-Id: | https://pubmed.ncbi.nlm.nih.gov/27916939 |
| Titel des übergeordneten Werkes (Englisch): | International journal of molecular sciences |
| Verlag: | Molecular Diversity Preservation International |
| Verlagsort: | Basel |
| Sonstige beteiligte Person(en): | Johannes Haybäck |
| Dokumentart: | Wissenschaftlicher Artikel |
| Sprache: | Englisch |
| Datum der Veröffentlichung (online): | 25.04.2017 |
| Jahr der Erstveröffentlichung: | 2016 |
| Veröffentlichende Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Datum der Freischaltung: | 25.04.2017 |
| Freies Schlagwort / Tag: | AIH immunopathogenesis; T cells; autoantibodies; chemokines: CYP2D6 model; cytokines |
| Jahrgang: | 17 |
| Ausgabe / Heft: | 12, Art. 2007 |
| Seitenzahl: | 19 |
| Erste Seite: | 1 |
| Letzte Seite: | 19 |
| Bemerkung: | © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
| HeBIS-PPN: | 42137036X |
| Institute: | Medizin / Medizin |
| DDC-Klassifikation: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Lizenz (Deutsch): |  Creative Commons - Namensnennung 4.0 |
