Latest documents http://publikationen.ub.uni-frankfurt.de/index/index/ Thu, 11 Dec 2008 11:34:58 +0100 Thu, 11 Dec 2008 11:34:58 +0100 http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/6010 A mild synthetic method for N-formyl-Met-Leu-Phe-OH (1) is described. After Fmoc solid phase peptide synthesis, on-bead formylation and HPLC purification, more than 30 mg of the fully 13C/15N-labelled tripeptide 1 could be isolated in a typical batch. This peptide can be easily crystallised and is therefore well suited as a standard sample for setting up solid-state NMR experiments. Sven Thomas Breitung; Jakob J. Lopez; Gerd Dürner; Clemens Glaubitz; Michael W. Göbel; Marcel Suhartono article http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/6010 Wed, 12 Nov 2008 11:34:58 +0100 http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/5844 C2-symmetric bisamidines 8 have been tested as chiral Brønsted bases in the Diels- Alder reaction of anthrones and N-substituted maleimides. High yields of cycloadducts and significant asymmetric inductions up to 76% ee are accessible. The proposed mechanism involves proton transfer between anthrone and bisamidine, association of the resulting ions and finally a cycloaddition step stereoselectively controlled by the chiral ion pair. Deniz Akalay; Gerd Dürner; Jan W. Bats; Michael W. Göbel article http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/5844 Thu, 25 Sep 2008 16:05:19 +0200