OPUS 4 Latest Documents RSS Feed Latest documents http://publikationen.ub.uni-frankfurt.de/index/index/ Fri, 31 Aug 2012 15:19:40 +0200 Fri, 31 Aug 2012 15:19:40 +0200 Synthesis of 1,4-Disubstituted Mono and Bis-triazolocarbo-acyclonucleoside Analogues of 9-(4-Hydroxybutyl)guanine by Cu(I)-Catalyzed Click Azide-Alkyne Cycloaddition http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/25939 A series of novel mono-1,2,3-triazole and bis-1,2,3-triazole acyclonucleoside analogues of 9-(4-hydroxybutyl)guanine was prepared via copper(I)-catalyzed 1,3-dipolar cycloaddition of N-9 propargylpurine, N-1-propargylpyrimidines/as-triazine with the azido-pseudo-sugar 4-azidobutylacetate under solvent-free microwave conditions, followed by treatment with K2CO3/MeOH, or NH3/MeOH. All compounds studied in this work were screened for their antiviral activities [against human rhinovirus (HRV) and hepatitis C virus (HCV)] and antibacterial activities against a series of Gram positive and negative bacteria. Jamal Krim; Mohamed Taourirte; Joachim W. Engels article http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/25939 Fri, 31 Aug 2012 15:19:40 +0200