Latest documents http://publikationen.ub.uni-frankfurt.de/index/index/ Thu, 14 Feb 2013 15:26:07 +0100 Thu, 14 Feb 2013 15:26:07 +0100 http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/28879 Two new and five known oxazoles were identified from two different Pseudomonas strains in addition to the known pyrones pseudopyronine A and B. Labeling experiments confirmed their structures and gave initial evidence for a novel biosynthesis pathway of these natural oxazoles. In order to confirm their structure, they were synthesized, which also allowed tests of their bioactivity. Additionally, the bioactivities of the synthesis intermediates were also investigated revealing interesting biological activities for several compounds despite their overall simple structures. Florian Grundmann; Veronika Dill; Andrea Dowling; Aunchalee Thanwisai; Edna Bode; Narisara Chantratita; Richard ffrench-Constant; Helge Björn Bode article http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/28879 Thu, 14 Feb 2013 15:26:07 +0100 http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/25206 The synthesis of the recently characterized depsipeptide szentiamide (1), which is produced by the entomopathogenic bacterium Xenorhabdus szentirmaii, is described. Whereas no biological activity was previously identified for 1, the material derived from the efficient synthesis enabled additional bioactivity tests leading to the identification of a notable activity against insect cells and Plasmodium falciparum, the causative agent of malaria. Friederike I. Nollmann; Andrea Dowling; Marcel Kaiser; Klaus Deckmann; Sabine Grösch; Richard ffrench-Constant; Helge Björn Bode article http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/25206 Wed, 27 Jun 2012 13:12:14 +0200