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Introduction: Neuronal death and subsequent denervation of target areas are hallmarks of many neurological disorders. Denervated neurons lose part of their dendritic tree, and are considered "atrophic", i.e. pathologically altered and damaged. The functional consequences of this phenomenon are poorly understood.
Results: Using computational modelling of 3D-reconstructed granule cells we show that denervation-induced dendritic atrophy also subserves homeostatic functions: By shortening their dendritic tree, granule cells compensate for the loss of inputs by a precise adjustment of excitability. As a consequence, surviving afferents are able to activate the cells, thereby allowing information to flow again through the denervated area. In addition, action potentials backpropagating from the soma to the synapses are enhanced specifically in reorganized portions of the dendritic arbor, resulting in their increased synaptic plasticity. These two observations generalize to any given dendritic tree undergoing structural changes.
Conclusions: Structural homeostatic plasticity, i.e. homeostatic dendritic remodeling, is operating in long-term denervated neurons to achieve functional homeostasis.
Ongoing demographic change will lead to a relative scarcity of raw labor to the effect that output growth will be decreasing in the next decades, a secular stagnation. As physical capital will be relatively abundant, this decrease of output will be accompanied by reductions of asset returns. We quantify these effects for the US economy by developing an overlapping generations model with risky and risk-free assets. Without adjustments of human capital, risky returns decrease until 2035 by about 0.7 percentage point, and the risk-free rate by about one percentage point, leading to substantial welfare losses for asset rich households. Per capita output is reduced by 6%. Endogenous human capital adjustments strongly mitigate these effects. We conclude that human capital policies will be crucial in the context of labor shortages.
European Music Portfolio (EMP) – Maths: 'Sounding ways into mathematics' : teacher’s handbook
(2016)
Music and mathematics share an odd character: many people believe that they are not good at one or the other (or both). However, ‘I cannot sing’ or ‘I never understood mathematics’ will probably not keep them from having successful careers, and nor will it change the opinions others have about them.
The project ‘European Music Portfolio – Sounding Ways into Mathematics’ (EMP-Maths) aims towards a different understanding with regards to this character. Everyone can sing and make music, and everyone can do mathematics. Both topics are integral parts of our life and society. What needs to be improved is our ability to give students opportunities to like them.
This teacher’s handbook presents activities with different mathematical and musical content in order to offer teachers resources, ideas and examples. These activities are designed to be expandable, adaptable to different contexts, and adjustable to the needs of each teacher and their students. Furthermore, these activities are not just planned to be carried out individually; a teaching unit could be used to make sense of them, or they could even be developed in connection with each other.
Apart from this teacher’s handbook, the project provides a continuing professional development (CPD) course, a webpage (http://maths.emportfolio.eu) from which all materials can be downloaded, and an online collaboration platform. A general overview of related literature and research is available in separate documents. Additional teacher booklets provide related materials and a brief overview of the theoretical background, and are the basis for the CPD courses. The project ‘Sounding Ways into Mathematics’ is related to the EMP-Languages project ‘A Creative Way into Languages’ (http://emportfolio.eu/emp/).
The general assumption that brain size differences are an adequate proxy for subtler differences in brain organization turned neurobiologists toward the question why some groups of mammals such as primates, elephants, and whales have such remarkably large brains. In this meta-analysis, an extensive sample of eutherian mammals (115 species distributed in 14 orders) provided data about several different biological traits and measures of brain size such as absolute brain mass (AB), relative brain mass (RB; quotient from AB and body mass), and encephalization quotient (EQ). These data were analyzed by established multivariate statistics without taking specific phylogenetic information into account. Species with high AB tend to (1) feed on protein-rich nutrition, (2) have a long lifespan, (3) delayed sexual maturity, and (4) long and rare pregnancies with small litter sizes. Animals with high RB usually have (1) a short life span, (2) reach sexual maturity early, and (3) have short and frequent gestations. Moreover, males of species with high RB also have few potential sexual partners. In contrast, animals with high EQs have (1) a high number of potential sexual partners, (2) delayed sexual maturity, and (3) rare gestations with small litter sizes. Based on these correlations, we conclude that Eutheria with either high AB or high EQ occupy positions at the top of the network of food chains (high trophic levels). Eutheria of low trophic levels can develop a high RB only if they have small body masses.
This is the eighth post in the blog series „Movements and Institutions“.
Occupy Wall Street has disappeared from the public radar, yet it is worth a second look. Through its structure and identity, it has probably become the United States’ first post-modern movement. Outside of formal institutions, people created their own utopian spaces in the hope for political and social innovation.
This is the seventh post in the blog series „Movements and Institutions“.
Social movements challenge systems of rule and thus institutions. They are expressions of the non-identical, the gaps and fissures in today’s world. That’s what makes social movements interesting and relevant for a critical research agenda. Thus, more than applying ready-made concepts to cases, scholars should inquire into the interactions between social movements and institutions as relationships between rule and resistance. This article proposes one way to go about such a critical research agenda.