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Aims: We have provided evidence in former studies that cytokines (IL-8, TNF alpha, LBP, TGFß) measured in blood correlate negatively with lung function in deltaF508 homozygous patients. GAP junction proteins might be of importance for the influx of blood cells into the lung. Our aim was to assess the relationship between connexin genotypes and cytokines (IL-8, TNF-alpha, LBP, TGFß) in induced sputum and serum, and lung disease.
Methods: 36 patients homozygous for deltaF508 (median age 18 y, m/f 16/20, FEV1(%) 77) were examined. Sequence analysis was performed for genes encoding GAP junction protein alpha 1 (GJA1/connexin 43) and gap junction protein alpha 4 (GJA4/connexin 37). Cytokines were assessed in serum and induced sputum (IS) by chemiluminescence (DPC Biermann, Bad Homburg, Germany) as well as leukocyte counts.
Results: DNA analysis was performed in 35 patients. Whereas GJA1 showed only one rare heterozygous synonymous SNP (rs138386744) in one patient, four common SNPs were detected in GJA4. Two were synonymous changes, but the third variant (rs41266431) predicts an amino acid substitution (GTA → valine, ATA → isoleucine) as well as the fourth SNP (rs1764391: CCC→proline, TCC→serine). For rs41266431 patients with homozygosity for the G variant had higher IL-8 levels (median: 13.3/8.0 pg/ml, p=0.07) in serum as well as leukocytes in sputum (median: 2050/421 /µl p=0.041) than those showing heterozygosity (G/A). In individuals > 30 years lung function (FEV1 41.3/84.83 % predicted, p=0.07) was worse.
Conclusion: SNP rs41266431 seems a promising candidate for further investigations, suggesting GJA4 a potential disease modifying gene.
Cultural heritage reconstructed - Compact Memory and the Frankfurt Digital Judaica Collection
(2014)
Compact Memory, the internet archive of German Jewish periodicals, provides free global internet access to the vast majority of German-Jewish newspapers and periodicals of the 19th and 20th century.
Jewish historical newspapers are the invaluable sources that supply direct and detailed information of the transformation process of Jewry and offer new insights into European Jewish history. The use of these historical sources however is extremely difficult, as complete sets of periodicals are very rarely to be found and they are scattered all over the world in different libraries and archives and in different physical formats (paper, microfilm).
Compact Memory contains the 110 most important Jewish German newspapers and periodicals in Central Europe in the period from 1806-1938, covering the complete range of religious, political, social, cultural and academic aspects of Jewish life. The texts are available partly as full-texts, processed by OCR, partly as graphic documents with corresponding index options. The database offers advanced search options, downloading and printing of articles. Thousands of essays of more than 10.000 individual contributors have been bibliographically indexed.
Compact Memory was established by the Judaica Division of the University Library Frankfurt am Main and in charge today in cooperation with the Aachen Chair of German-Jewish Literary History and the Cologne library Germania Judaica.
Compact Memory is one database within the Digital Collection Judaica which being part of Europeana and other digital portals offers resources for the reconstruction and representation of Jewish cultural heritage.
We investigate the properties of the QCD matter across the deconfinement phase transition. In the scope of the parton-hadron string dynamics (PHSD) transport approach, we study the strongly interacting matter in equilibrium as well as the out-of equilibrium dynamics of relativistic heavy-ion collisions. We present here in particular the results on the electromagnetic radiation, i.e. photon and dilepton production, in relativistic heavy-ion collisions and the relevant correlator in equilibrium, i.e. the electric conductivity. By comparing our calculations for the heavy-ion collisions to the available data, we determine the relative importance of the various production sources and address the possible origin of the observed strong elliptic flow ν2 of direct photons.
We have studied one-proton-removal reactions of about 500MeV/u 17Ne beams on a carbon target at the R3B/LAND setup at GSI by detecting beam-like 15O-p and determining their relative-energy distribution. We exclusively selected the removal of a 17Ne halo proton, and the Glauber-model analysis of the 16F momentum distribution resulted in an s2 contribution in the 17Ne ground state of about 40%.
We discuss recent applications of the partonic perturbative QCD based cascade model BAMPS with focus on heavy-ion phenomenology in the hard and soft momentum range. First, the elliptic flow and suppression of charm and bottom quarks are studied at LHC energies. Thereafter, we compare in a detailed study the standard Gunion-Bertsch approximation of the matrix elements for inelastic processes to the exact results in leading order perturbative QCD. Since a disagreement is found, we propose an improved Gunion-Bertsch matrix element, which agrees with the exact result in all phase space regions.
We present results for calculating fusion cross-sections using a new microscopic approach based on a time-dependent density-constrained DFT calculations. The theory is implemented by using densities and other information obtained from TDDFT time-evolution of the nuclear system as a constraint on the density for DFT calculations.
D2.1. provides further elaboration of the original research design and informs about ideas for the final Volume II of bEUcitizen. It is closely connected to task 1 of work package 2: specifying various concrete tasks for the different work packages and formulating overarching questions suitable to provide substantive cohesion and integration of the overall project. The elaboration of 10 crosscutting topics (to become chapters in the “horizontal” book, D2.3.) is a first step towards this goal. Discussing these cross-cutting topics is supposed to feed, infuse and inspire the work done in the different work packages and to build cross-cutting connections between them. Themes 1-10 merge into a valuable overview of the multi-faceted research on (EU) citizenship. They access the main issues of EU-citizenship and citizenship in general from different angles and different disciplines. Taken together these contributions help to identify barriers towards EU citizenship and ways to overcome them. Each Theme formulates questions how it might feed and be fed by further information and findings in the other work packages.
D2.1. is mainly meant for internal use. Its functions are firstly to inform about preliminary ideas, eventual contributions to planned final results and secondly to make out some more of less specific guiding questions that connect the work done by the single researchers in every different work package to the project as a whole. This task implies a normative yardstick, a clear picture of what would be a "good" EU citizenship practice. Elaborating on such a normative yardstick is a meta-topic that cuts across the range of cross-cutting topics presented in this working paper.
Europeana provides a common access point to digital cultural heritage objects across different cultural domains among which the libraries. The recent development of the Europeana Data Model (EDM) provide new ways for libraries to experiment with Linked Data. Indeed the model is designed as a framework reusing various wellknown standards developed in the Semantic Web Community, such as the Resource Description Framework (RDF), the OAI Object Reuse and Exchange (ORE), and Dublin Core namespaces. It provides new opportunities for libraries to provide rich and interlinked metadata to the Europeana aggregation.
However to be able to provide data to Europeana, libraries need to create mappings from the librarystandard to EDM. This step involves decisions based on domainspecific requirements and on the possibilities offered by EDM. The crossdomain nature of EDM limiting in some cases the completeness of the mappings, extension of the model have been proposed to accommodate the library needs.
The "Digitised Manuscripts to Europeana" project (DM2E) has created an extension of EDM to optimise the mappings of librarydata for manuscripts. This extension is in the form of subclasses and subproperties that further specialise EDM concepts and properties. It includes spatial creation and publishing information, specific contributor and publication type properties and more.
Furthermore the granularity of the mapping has been extended to allow references and annotations on page level as required for scholarly work. As part of this project the metadata of the Hebrew Manuscripts as well as of the Medieval Manuscripts presented in the Digital Collections of the Frankfurt University Library have been mapped to this extension. This includes links to the Integrated Authority File (GND) of the German National Library with further links to the Virtual International Authority File (VIAF).
Based on this development a new comprehensive mapping from the digitalisation metadata format METS/MODS to EDM has been established for all materials of the Frankfurt Judaica in "Judaica Europeana ". It demonstrates today’s capabilities of the creation of linked Data structures in Europeana based on library catalogue data and structural data from the digitalisation process.