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Ribosomal RNA undergoes various modifications to optimize ribosomal structure and expand the topological potential of RNA. The most common nucleotide modifications in ribosomal RNA (rRNA) are pseudouridylations and 2'-O methylations (Nm), performed by H/ACA box snoRNAs and C/D box snoRNAs, respectively. Furthermore, rRNAs of both ribosomal subunits also contain various base modifications, which are catalysed by specific enzymes. These modifications cluster in highly conserved areas of the ribosome. Although most enzymes catalysing 18S rRNA base modifications have been identified, little is known about the 25S rRNA base modifications. The m(1)A modification at position 645 in Helix 25.1 is highly conserved in eukaryotes. Helix formation in this region of the 25S rRNA might be a prerequisite for a correct topological framework for 5.8S rRNA to interact with 25S rRNA. Surprisingly, we have identified ribosomal RNA processing protein 8 (Rrp8), a nucleolar Rossman-fold like methyltransferase, to carry out the m(1)A base modification at position 645, although Rrp8 was previously shown to be involved in A2 cleavage and 40S biogenesis. In addition, we were able to identify specific point mutations in Rrp8, which show that a reduced S-adenosyl-methionine binding influences the quality of the 60S subunit. This highlights the dual functionality of Rrp8 in the biogenesis of both subunits.
This short story collection is the outcome of the writing residency for African women writers held in Jinja, Uganda, in January 2011. Writers from across English-speaking Africa contribute stories as diverse as the continent itself, stories that explore universal concerns in acutely individual ways. Among others, an upper-class Ghanaian confronts the irony of race from a prison cell; a Zambian mourns her sister and tackles the restrictions of tradition in a surprisingly humorous way; in Tanzania, two strangers go to extremes to seek elusive health; a Ugandan housewife reflects on personal and world politics as she watches a dog fight; another Ghanaian remembers a love affair that led her into an ancestor's embrace; two Nigerians shopping in London get more than they bargained for; and in a 2011 Caine Prize nominated story by Ugandan writer Beatrice Lamwaka, children cry tears of pain and happiness during an armed conflict.
An illustrated description of Withius hispanus (L. Koch, 1873) is provided based on its morphological and morphometric characters. This finding of W. hispanus is the first record of the family Withiidae in Slovakia. The present re-description of this species allows an assessment of the variability of its morphological and morphometric characters.
This book is largely the personal account by Patrick Mbunwe Samba, of how life in his home village of Binshua has been permeated throughout by belief in witchcraft. The book not only provides a historical account informed by his reminiscences of his childhood, it shows as well that even today, belief in witchcraft is very widespread. Witchcraft exerts a profound influence on society in Binshua and in Cameroon in general. The book also provides accounts of the experiences of others, some of them very recent, and gives examples of what injustices and suffering can be caused by the notion that any misfortune must have been caused by witchcraft. For the overwhelming majority of people in village communities such as Binshua, Samba argues, anything not immediately understandable is witchcraft - which is synonymous with mystery. Many educated Africans, too, revert to such traditional attitudes in stressful situations. It may be thought surprising that in spite of the impact of Christianity, Western culture and the improved level of education, the majority of people still believe in witchcraft, and that this phenomenon not only persists but is actually increasing. The book perplexes and challenges by avoiding to provide simple answers to the question whether which witchcraft is real or imagined.
This is a comparative ethnographic study of witchcraft and associated violence between the kingdoms of Kom and Venda in Cameroon and South Africa respectively. The book shows why despite its prevalence in both societies, witchcraft does not lead to open violence in Kom, while such large-scale violence is commonplace in Venda. It reveals that this difference can be explained by factors such as the variations in local ideas on witches, differences in the role of traditional authorities, and various state interventions on witchcraft matters. The book demonstrates, through a rich collection of detailed cases, that contrary to anthropological theory that views witchcraft as a mechanism for the expression and resolution of social tensions and conflicts, witchcraft may at times become a disturbance of amicable social relations. Witchcraft accusations may occur in a context where strained social relations have not preceded them. The knowledge and experience that people have about witchcraft is sufficient to trigger an accusation and a violent reaction. Different forms of witchcraft account for variations in witchcraft attributions and accusations. This comparison provides a valuable contribution to ongoing witchcraft policy discourse amid widespread citizen anxiety over witchcraft, and the increasing call on the post-colonial state to intervene and protect its citizens against occult aggression.
The paper presents a study which was based on the hypothesis that wikis that are initiated bottom up by students might be used more deliberately than wikis which are introduced top down by teachers. Therefore it examines the specific effects observed in nine different wiki projects at the university of Frankfurt ranging from student wiki projects up to wikis used in seminars and as information tool for institutions.