Refine
Year of publication
Document Type
- Article (30440) (remove)
Language
- English (15150)
- German (13284)
- Portuguese (696)
- French (387)
- Croatian (251)
- Spanish (250)
- Italian (132)
- Turkish (113)
- Multiple languages (36)
- Latin (35)
Has Fulltext
- yes (30440)
Keywords
- Deutsch (503)
- taxonomy (420)
- Literatur (297)
- Hofmannsthal, Hugo von (185)
- Rezeption (178)
- new species (178)
- Übersetzung (163)
- Filmmusik (155)
- Johann Wolfgang von Goethe (131)
- Vormärz (113)
Institute
- Medizin (5097)
- Physik (1726)
- Extern (1108)
- Biowissenschaften (1100)
- Biochemie und Chemie (1091)
- Gesellschaftswissenschaften (798)
- Frankfurt Institute for Advanced Studies (FIAS) (696)
- Geowissenschaften (582)
- Präsidium (453)
- Philosophie (448)
Borstgrasrasen treten in Rheinland-Pfalz vor allem in den Höhenlagen der Mittelgebirge auf. Auf trockenen bis frischen Böden gehören die Bestände dem Violion caninae Schwick. 1944 an. Innerhalb des Verbandes zeigt sich ein starker Gradient in den Basengehalten. Das Juncetum squarrosi Nordh. 1923 besiedelt feuchte Böden. Unterschiedliche Ausbildungsformen im gemähten Grünland, Brachland und als Pioniergesellschaften auf Waldwegen werden beschrieben.
Auf ehemals militärisch genutzten Liegenschaften wurden unterschiedliche Wiesen-, Magerrasen- und Pioniergesellschaften untersucht. Es werden Bestände der Sedo-Scleranthetea, Nardo-Callunetea, Festuco-Brometea, Molinio-Arrhenatheretea und Isoeto-Nanojuncetea beschrieben. Das Grünland zeichnet sich durch Großflächigkeit und Artenarmut (insbesondere an Charakterarten) aus. Vor allem auf trockenen, nassen bzw. mageren Sonderstandorten kommen einzelne gefährdete Pflanzenarten vor. Die teils erheblichen nutzungsbedingten Vorbelastungen werden dargestellt und Entwicklungskonzepte diskutiert.
We review the effective field theory associated with the superfluid phonons that we use for the study of transport properties in the core of superfluid neutrons stars in their low temperature regime. We then discuss the shear and bulk viscosities together with the thermal conductivity coming from the collisions of superfluid phonons in neutron stars. With regard to shear, bulk, and thermal transport coefficients, the phonon collisional processes are obtained in terms of the equation of state and the superfluid gap. We compare the shear coefficient due to the interaction among superfluid phonons with other dominant processes in neutron stars, such as electron collisions. We also analyze the possible consequences for the r-mode instability in neutron stars. As for the bulk viscosities, we determine that phonon collisions contribute decisively to the bulk viscosities inside neutron stars. For the thermal conductivity resulting from phonon collisions, we find that it is temperature independent well below the transition temperature. We also obtain that the thermal conductivity due to superfluid phonons dominates over the one resulting from electron-muon interactions once phonons are in the hydrodynamic regime. As the phonons couple to the Z electroweak gauge boson, we estimate the associated neutrino emissivity. We also briefly comment on how the superfluid phonon interactions are modified in the presence of a gravitational field or in a moving background.
Understanding how temperature affects cod (Gadus morhua) ecology is important for forecasting how populations will develop as climate changes in future. The effects of spawning-season temperature and habitat size on cod recruitment dynamics have been investigated across the North Atlantic. Ricker and Beverton and Holt stock–recruitment (SR) models were extended by applying hierarchical methods, mixed-effects models, and Bayesian inference to incorporate the influence of these ecosystem factors on model parameters representing cod maximum reproductive rate and carrying capacity. We identified the pattern of temperature effects on cod productivity at the species level and estimated SR model parameters with increased precision. Temperature impacts vary geographically, being positive in areas where temperatures are <5°C, and negative for higher temperatures. Using the relationship derived, it is possible to predict expected changes in population-specific reproductive rates and carrying capacities resulting from temperature increases. Further, carrying capacity covaries with available habitat size, explaining at least half its variability across stocks. These patterns improve our understanding of environmental impacts on key population parameters, which is required for an ecosystem approach to cod management, particularly under ocean-warming scenarios. Key words: carrying capacity , cod , hierarchical models , North Atlantic , temperature , uncertainty
Background: The brain cancer stem cell (CSC) model describes a small subset of glioma cells as being responsible for tumor initiation, conferring therapy resistance and tumor recurrence. In brain CSC, the PI3-K/AKT and the RAS/mitogen activated protein kinase (MAPK) pathways are found to be activated. In consequence, the human transcription factor YB-1, knowing to be responsible for the emergence of drug resistance and driving adenoviral replication, is phosphorylated and activated. With this knowledge, YB-1 was established in the past as a biomarker for disease progression and prognosis. This study determines the expression of YB-1 in glioblastoma (GBM) specimen in vivo and in brain CSC lines. In addition, the capacity of Ad-Delo3-RGD, an YB-1 dependent oncolytic adenovirus, to eradicate CSC was evaluated both in vitro and in vivo.
Methods: YB-1 expression was investigated by immunoblot and immuno-histochemistry. In vitro, viral replication as well as the capacity of Ad-Delo3-RGD to replicate in and, in consequence, to kill CSC was determined by real-time PCR and clonogenic dilution assays. In vivo, Ad-Delo3-RGD-mediated tumor growth inhibition was evaluated in an orthotopic mouse GBM model. Safety and specificity of Ad-Delo3-RGD were investigated in immortalized human astrocytes and by siRNA-mediated downregulation of YB-1.
Results: YB-1 is highly expressed in brain CSC lines and in GBM specimen. Efficient viral replication in and virus-mediated lysis of CSC was observed in vitro. Experiments addressing safety aspects of Ad-Delo3-RGD showed that (i) virus production in human astrocytes was significantly reduced compared to wild type adenovirus (Ad-WT) and (ii) knockdown of YB-1 significantly reduced virus replication. Mice harboring othotopic GBM developed from a temozolomide (TMZ)-resistant GBM derived CSC line which was intratumorally injected with Ad-Delo3-RGD survived significantly longer than mice receiving PBS-injections or TMZ treatment.
Conclusion: The results of this study supported YB-1 based virotherapy as an attractive therapeutic strategy for GBM treatment which will be exploited further in multimodal treatment concepts.
Gegenstand dieser Untersuchung sind zwei Ackerbrachen westlich Fürstenberg/Havel (Nordbrandenburg). Mit Hilfe von 16 ökologisch-soziologischen Artengruppen können 7 Vegetationsformen der Ackerbrachen ausgeschieden werden. Diese werden weiterhin durch wichtige Standorteigenschaften und ihre Physiognomie charakterisiert. Die pflanzensoziologische Einordnung der Vegetationsformen wird diskutiert. Die beschriebenen Vegetationsformen der Ackerbrachen werden in standörtlich homologe Reihen unterschiedlicher Nutzung eingeordnet (Acker-Ackerbrache-Grünland/Ruderalflur). Auf großen Teilen der Ackerbrachen erfolgt aufgrund des überwiegend sandigen Substrats eine schnelle Entwicklung in Richtung zu Grasnelken-Schafschwingelrasen (Diantho-Armerietum Krausch 1959). In den nährstoffreichen, kolluvial beeinflußten Senken etablieren sich dagegen dauerhafte Quecken-Dominanzbestände. Die kleinflächig auftretenden Decklehm- bzw. Sand-Rendzinen sowie die Tieflehm-Fahlerden weisen jeweils abweichende Vegetationsentwicklungen auf.
High-performance liquid chromatography (HPLC) has proved extremely versatile over the past 25 yr for the isolation and punfication of peptides varying widely in their sources, quantity and complexity. This article covers the major modes of HPLC utilized for peptides (size-exclusion, ion-exchange, and reversed-phase), as well as demonstrating the potential of a novel mixed-mode hydrophilic interaction/cation-exchange approach developed in this laboratory. In addition to the value of these HPLC modes for peptide separations, the value of various HPLC techniques for structural characterization of peptides and proteins will be addressed, e.g., assessment of oligomerization state of peptideslproteins by sizeexclusion chromatography and monitoring the hydrophilicitykydrophobicity of amphipathic cr-helical peptides, a vital precursor Tor the development of novel antimicrobial peptides. The value of capillary electrophoresis for peptide separations is also demonstrated. Preparative reversed-phase chromatography purification protocols for sample loads of up to 200 mg on analytical columns and instrumentation are introduced for both peptides and recombinant proteins. Key Words: Peptides; proteins; size-exclusion chromatography (SEC); anion-exchange chromatography (AEX); cation-exchange chromatography (CEX); mixed-mode hydrophilic interaction chromatography (HIL1C)/cation-exchange chromatography (CEX); reversed-phase high-performance liquid chromatography (RP-HPLC); preparative RP-HPLC of peptides and proteins; amino acid side-chain hydrophilicitylhydrophobicity coefficients; amino acid U-helical propensity values; amino acid side-chain stability coefficients
Sustainability orientation has a positive effect on startups' initial valuation and a negative effect on their post-funding financial performance. All else equal, improving sustainability orientation by one standard deviation increases startups' funding amount by 28 % and decreases investors' abnormal returns per post-funding year by 16 %. The results hold in a large sample of blockchain-based crowdfunding campaigns, also known as Initial Coin Offerings (ICOs) or token offerings. A key contribution is a machine-learning approach to assess startups' Environment, Society and Governance (ESG) properties from textual data, which we make readily available at www.SustainableEntrepreneurship.org.
Literaturkanon und Identitätspolitik. Notizen zu den Wiener Schillerfeiern im 19. Jahrhundert
(2020)
Der vorliegende Beitrag befasst sich mit der Inszenierung Friedrich Schillers als Leitfigur einer deutschen Kulturnation bei der Wiener Dichterfeier 1859. Gemessen an der politischen Krisensituation der Habsburgermonarchie spiegelt die Zentenarfeier die kollektiven Sehnsüchte und Illusionen des deutschösterreichischen Bürgertums deutlich wider. Die einzelnen Veranstaltungen können hierbei als Medienereignisse und "Cultural Performances" aufgefasst werden, bei denen die politisch intendierten Festinhalte vermittelt und sinnlich erfahrbar gemacht wurden. Die Indienstnahme und Popularisierung Schillers trieb nicht zuletzt auch dessen Kanonisierung weiter voran – literatur- und theaterhistorisch betrachtet nicht immer zum Vorteil der "österreichischen Literatur" des 18. und 19. Jahrhunderts.