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Der Sammelband enthält die Vorträge einer altertumswissenschaftlichen Tagung, die unter gleichem Titel am Freiburger Antike-Zentrum (dort auch "Antikenzentrum" genannt) stattfand und an der Historiker, Kirchenhistoriker, Philologen und Philosophen teilgenommen haben. ...
Hartmut Leppin dokumentiert exemplarisch das Eindringen christlichen Geistes in das traditionelle Kaiserbild. ...
Sealsfields Mobilität, die ihn zwischen 1823 und 1858 viermal zwischen den Kontinenten pendeln lässt, rhythmisiert sein Leben und Arbeiten. Sie ist die Voraussetzung seiner transatlantischen Doppelperspektive, übernationalen Geschichtssicht wie international wirksamen publizistischen Vorgehensweise und liefert die Zäsuren für ein Agieren, das in zwei Phasen erfolgt, abhängig vom Wohnsitz in den USA und in Europa. Daran orientieren sich die nachfolgenden Ausführungen. Deren Ziel ist es an Hand der Buchveröffentlichungen zu erläutern, wie Sealsfield für seine innovative Schreib- und internationalisierte Vermarktungsstrategie potente Verlage als nützliche Dienstleister funktionalisiert und so das engagierte Erzählkonzept für die Selbstorganisation im literarsozialen Gefüge des Vormärz umsetzt.
Im Rahmen dieser Arbeit wird ein Gammaspektroskopie-Aufbau unter Verwendung eines HPGe-Clover-Detektors zur Nutzung in Aktivierungsexperimenten charakterisiert und untersucht. Die für präzise Aktivitätsmessungen nach einer Aktivierung nötigen Effizienzen werden mit Hilfe der Eichquellen 60Co und 22Na unter Nutzung verschiedener Modi des Clover-Detektors abstandsabhängig errechnet. „Listmode“-Daten ermöglichen dabei eine „offline“-Verarbeitung. Begleitet werden die Messungen von aufwändigen Monte-Carlo-Simulationen in Geant4. Parallele Auswertungsmethoden erlauben einen genauen Vergleich zwischen simulierten und experimentellen Ergebnissen.
U radu se opisuju primjeri češće uporabe akuzativa bez prijedloga u suvremenim hrvatskim medijima i razgovornom jeziku. Primjeri se takve uporabe razvrstavaju u nekoliko skupina: 1. sintagme s nepunoznačnim glagolom i besprijedložnim akuzativom, 2. glagol + *imenska riječ (A) + imenska riječ (A) < glagol + od + imenska riječ (G) + imenska riječ (A), 3. neprijelazni glagol → prijelazni glagol. Među sintagmama s akuzativom promjene se primjećuju i u sljedećoj, 4. skupini: glagol + unutrašnji objekt → glagol + hiponimni objekt (rubni izravni objekt?). Pri opisu se potvrđuje da se akuzativ kao puni, središnji padež, kojim se predmet obuhvaća u potpunosti, nameće rubnosti ostalih perifernih padeža, pr. instrumentala (kod glagola kontaktirati). Pokazuje se da su, usprkos normi koja uz glagole traženja ne preporuča uporabu dvaju akuzativa bez prijedloga, nego jednoga besprijedložnoga akuzativa (ili dijelnoga genitiva) te drugoga genitiva s prijedlogom od, uz glagol tražiti u jeziku suvremenih medija česte potvrde dvaju besprijedložnih akuzativa.
Rezension zu: Julian Millie: Splashed by the saint. Ritual reading and islamic sanctity in West Java
(2011)
"Vom Heiligen bespritzt. Rituelle Lesung und muslimische Heiligkeit in Westjava" ist der aus dem Englischen wörtlich übersetzte Titel einer modernen Ethnografie zum Sunda-Gebiet. Wie in einer klassischen Ethnografie wird ein bestimmtes Ritual ins Zentrum der Untersuchung gerückt. Es handelt sich dabei um eine Lesung, die sich auf "Heiligkeit" bezieht und deshalb vom Autor als karamat-Lesung (Arab.: karamat - charismatische und/oder mystische Kraft) bezeichnet wird. Die Lesungen finden entweder im privaten, häuslichen Umfeld oder in einem Pesantren (muslimisches Internat) statt, wo sie von jedem Interessenten besucht werden können. Kern des Rituals sind Texte über Abd al-Qadir al-Jaelani, den die Ritualteilnehmer als Mittler zu Allah verstehen, und an dessen Heiligkeit sie Anteil haben können. Interessant ist dabei, dass Abd al Qadir kein autochthoner Urahn ist. Der Legende nach wurde er 1088 n. Chr. in Gilan im Iran geboren und in Bagdad beerdigt, wo sein Grabmal zu einer Pilgerstätte von Muslimen aus aller Welt geworden ist. Erklärtes Ziel des Autors ist es, zu untersuchen, was ritualisiertes Lesen und die Rezitation sakraler Erzählungen über Islamische Frömmigkeit und über den Raum, den die Texte in der muslimischen Gesellschaft einnehmen, aussagen.
The Alor-Pantar Archipelago is still one of the most under-researched areas of Indonesia. However, in January 2009 I was able to collect data on anthropomorphic sculptures in the Tanjung Muna area of Pantar. The study used photographs of objects that had been purchased recently by European private art collectors in order to elicit responses regarding the local mythology. I was also able to interview local traders as well as the dealer who sold the sculptures, which allowed me to document information regarding their origin and former use, as well as the circumstances under which they had found their way on to the international art market. Traditional marriage rules as well as black magic played a central role. Furthermore, in the course of my research by chance I learned of a contemporary ancestor cult connected to the construction of a new clan house and of traditional (pre-Protestant) forms of healing.
The asymmetric unit of the title compound, C16H23ClN2O, comtains two independent molecules in which the fused-ring systems are essentially planar, the largest deviation from the mean plane of each molecule being 0.011 (2) Å and 0.016 (2) Å. The benzimidazole rings of the two molecules make a dihedral angle of 66.65 (7)°. The nonyl substituents are almost perpendicular to the benzimidazole planes [C—N—C—C tosrsion angles = 96.0 (3) and 81.0 (2)°]. In the crystal, each independent molecule forms an inversion dimer via a pair of N—H[cdots, three dots, centered]O hydrogen bonds. In one of the independent molecules, the terminal –CH2–CH3 group of the alkyl chain is disordered over two sets of sites with a refined occupancy ratio of 0.746 (7):0.254 (7).
In the molecular structure of the title compound, C21H18N2O, the fused-ring system is essentially planar, the largest deviation from the mean plane being 0.0121 (9) Å. The O atom and adjacent C atom are located in Wyckoff position 4e on a twofold axis (0, y, 1/4). The two benzyl groups are almost perpendicular to the benzimidazole plane, but point in opposite directions. The dihedral angle between the benzimidazole mean plane and the phenyl ring is 81.95 (5)°, whereas that between the two benzyl groups is 60.96 (7)°.
Introduction: Current prognostic gene expression profiles for breast cancer mainly reflect proliferation status and are most useful in ER-positive cancers. Triple negative breast cancers (TNBC) are clinically heterogeneous and prognostic markers and biology-based therapies are needed to better treat this disease.
Methods: We assembled Affymetrix gene expression data for 579 TNBC and performed unsupervised analysis to define metagenes that distinguish molecular subsets within TNBC. We used n = 394 cases for discovery and n = 185 cases for validation. Sixteen metagenes emerged that identified basal-like, apocrine and claudin-low molecular subtypes, or reflected various non-neoplastic cell populations, including immune cells, blood, adipocytes, stroma, angiogenesis and inflammation within the cancer. The expressions of these metagenes were correlated with survival and multivariate analysis was performed, including routine clinical and pathological variables.
Results: Seventy-three percent of TNBC displayed basal-like molecular subtype that correlated with high histological grade and younger age. Survival of basal-like TNBC was not different from non basal-like TNBC. High expression of immune cell metagenes was associated with good and high expression of inflammation and angiogenesis-related metagenes were associated with poor prognosis. A ratio of high B-cell and low IL-8 metagenes identified 32% of TNBC with good prognosis (hazard ratio (HR) 0.37, 95% CI 0.22 to 0.61; P < 0.001) and was the only significant predictor in multivariate analysis including routine clinicopathological variables.
Conclusions: We describe a ratio of high B-cell presence and low IL-8 activity as a powerful new prognostic marker for TNBC. Inhibition of the IL-8 pathway also represents an attractive novel therapeutic target for this disease.
RcsF, a proposed auxiliary regulator of the regulation of capsule synthesis (rcs) phosphorelay system, is a key element for understanding the RcsC-D-A/B signaling cascade, which is responsible for the regulation of more than 100 genes and is involved in cell division, motility, biofilm formation, and virulence. The RcsC-D-A/B system is one of the most complex bacterial signal transduction pathways, consisting of several membrane-bound and soluble proteins. RcsF is a lipoprotein attached to the outer membrane and plays an important role in activating the RcsC-d-A/B pathway. The exact mechanism of activation of the rcs phosphorelay by RcsF, however, remains unknown. We have analyzed the sequence of RcsF and identified three structural elements: 1) an N-terminal membrane-anchored helix (residues 3-13), 2) a loop (residues 14-48), and 3) a C-terminal folded domain (residues 49-134). We have determined the structure of this C-terminal domain and started to investigate its interaction with potential partners. Important features of its structure are two disulfide bridges between Cys-74 and Cys-118 and between Cys-109 and Cys-124. To evaluate the importance of this RcsF disulfide bridge network in vivo, we have examined the ability of the full-length protein and of specific Cys mutants to initiate the rcs signaling cascade. The results indicate that the Cys-74/Cys-118 and the Cys-109/Cys-124 residues correlate pairwise with the activity of RcsF. Interaction studies showed a weak interaction with an RNA hairpin. However, no interaction could be detected with reagents that are believed to activate the rcs phosphorelay, such as lysozyme, glucose, or Zn(2+) ions.