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Das nach der FFH-Richtlinie zu schützende Kugel-Hornmoos wurde seit 2002 im hessischen Vogelsberg auf 39 Ackerparzellen nachgewiesen. Neben denen in Rheinland-Pfalz, Bayern und Tschechien sind dies die umfangreichsten Vorkommen des Kugel-Hornmooses in Mitteleuropa und das Bundesland Hessen hat eine große Verantwortung für deren Fortbestand
Novel insights into the synergistic interaction of Bortezomib and TRAIL: tBid provides the link
(2011)
The proteasome inhibitor Bortezomib has been identified as a potent enhancer of TRAIL-induced apoptosis in several human cancers. However, the identification of the underlying molecular mechanisms of this synergistic cell death induction has been ongoing over the last years. A recent study identifies a new mechanism of action for the synergism of TRAIL and Bortezomib.
Chickpea (Cicer arietinum L.) is the third most important cool season food legume, cultivated in arid and semi-arid regions of the world. The goal of this study was to develop novel molecular markers such as microsatellite or simple sequence repeat (SSR) markers from bacterial artificial chromosome (BAC)-end sequences (BESs) and diversity arrays technology (DArT) markers, and to construct a high-density genetic map based on recombinant inbred line (RIL) population ICC 4958 (C. arietinum)×PI 489777 (C. reticulatum). A BAC-library comprising 55,680 clones was constructed and 46,270 BESs were generated. Mining of these BESs provided 6,845 SSRs, and primer pairs were designed for 1,344 SSRs. In parallel, DArT arrays with ca. 15,000 clones were developed, and 5,397 clones were found polymorphic among 94 genotypes tested. Screening of newly developed BES-SSR markers and DArT arrays on the parental genotypes of the RIL mapping population showed polymorphism with 253 BES-SSR markers and 675 DArT markers. Segregation data obtained for these polymorphic markers and 494 markers data compiled from published reports or collaborators were used for constructing the genetic map. As a result, a comprehensive genetic map comprising 1,291 markers on eight linkage groups (LGs) spanning a total of 845.56 cM distance was developed (http://cmap.icrisat.ac.in/cmap/sm/cp/thudi/). The number of markers per linkage group ranged from 68 (LG 8) to 218 (LG 3) with an average inter-marker distance of 0.65 cM. While the developed resource of molecular markers will be useful for genetic diversity, genetic mapping and molecular breeding applications, the comprehensive genetic map with integrated BES-SSR markers will facilitate its anchoring to the physical map (under construction) to accelerate map-based cloning of genes in chickpea and comparative genome evolution studies in legumes.
High grade gliomas, including anaplastic glioma WHO grade III and glioblastoma WHO IV (GBM), carry a dismal prognosis. Taking all nowadays-available therapeutics options, including radiation, chemotherapy and surgery, for GBM into consideration the prognosis after initial diagnosis is about 12 month. Despite this bad prognosis, researchers gained a tremendous insight into the molecular and genetic signatures of low and high grade gliomas. Several different subtypes of GBM were demonstrated with respect to their genetic background. These genetic alterations include p53 mutation in secondary GBMs and EGFR amplification in primary GBMs, respectively. Very recently, great excitement was raised after the discovery of IDH1 mutation in low-grade gliomas and secondary GBMs. This discovery is of great significance since it allows further categorizing of GBMs and is helpful in distinguishing low-grade gliomas from non-neoplastic adjacent brain tissue. Despite all this progress there is an urgent need for fresh additional therapeutic strategies. In addition to the identification of novel therapeutic regimens it is of utmost importance to gain an understanding about the molecular mechanisms on how GBMs manage to evade from almost any anti-cancer treatment regimen. In experimental models of glioblastoma there are a number of novel therapeutic regimens that exhibited promising results. These novel therapeutics include, but are not limited to: Apoptosis-based therapeutics (Tumor necrosis factor alpha related apoptosis inducing ligand, TRAIL), tyrosinkinase-inhibitors, Heat-shock-protein 90 (HSP90) inhibitors, polyphenols, novel drug combinations and intracranial application based strategies. This chapter will primarily review and focus on molecular mechanisms of resistance in GBM and rising new therapeutic venues for high-grade gliomas. High-grade gliomas are a group of primary heterogenous tumors of which glioblastoma World Health Organisation, WHO IV (GBM), is the most common one. Once the diagnosis of GBM is made, the average survival time is approximately 12-15 month (Hegi, Diserens et al., 2005). Treatment usually consists of temozolomide (commonly used chemotherapeutic drug for the treatment of GBM, TMZ), radiation (either alone or in combination with chemotherapeutics) and surgery (Hegi, Diserens et al., 2005)...
Nso' and Its Neighbours : Readings in the Social History of the Western Grassfields of Cameroon
(2011)
This is a rich and compelling volume of readings in social history on Nsoí and its neighbours in the Western Grassfields of Cameroon. It consists of 19 essays by some of the leading historians, archeologists and ethnographers of the region, with seminal contributions by Jean-Pierre Warnier, Paul Nchoji Nkwi, Bongfen Chem-Langhee, Phyllis Kaberry, E.M Chilver, Miriam Goheen, Ian Flower, Dan Lantum and V.G. Fanso. The book covers a broad range of themes from precolonial times to date, including trade, alliances, diplomacy, the iron industry, colonial impact, continuities, discontinuities and compromise, general persistence, ideology and conflict. Warnier draws on linguistic and archaeological data to argue that this region has been settled for several millennia, very probably continuously, and that its landscapes are very ancient and have resulted from many human and natural forces other than the simple clearance of the forest cover of the region at an uncertain date as some authors have postulated. Using data on inter-group diplomacy and alliances, Nkwi puts into question some problematic theses on persistence hostilities and enhances knowledge of the precolonial history of the region. Fowler and Chem-Langhee show how local conditions and needs fostered the spirit and practice of cooperative ventures in the precolonial period, which provided the driving force and the ideological and structural underpinnings for the successful and smooth introduction of modern modes of cooperation in the area during the colonial and postcolonial periods. The rest of the studies have a unifying theme or thesis, namely, that despite the entry and assault of external, influences, particularly those associated with colonialism, Christianity and Islam, the traditional institutions, customs and value systems of the Nsoí and their neighbours have resisted major change and their total corrosion is not yet in sight. The volume illustrates the proposition that historical research is a continuous process of rediscovery which provides new questions, and also that the evidence of other disciplines - linguistics, archaeology and palaeobotany for example - may give rise to many new lines of inquiry and help to correct the documentary record and explain oral tradition. Herein lies the most important element of this experimental collection. Its editors hope that it will provoke other similar collections.
Numerical simulation of flow, H2SO4 cycle and new particle formation in the CERN CLOUD chamber
(2011)
To study the effect of galactic cosmic rays on aerosols and clouds, the Cosmic Leaving OUtdoor Droplets (CLOUD) project was established. Experiments are carried out at a 26 m3 tank at CERN (Switzerland). In the experiments, the effect of ionising particle radiation on H2SO4 particle formation and growth is investigated. To evaluate the experimental configuration, the experiment was simulated using a coupled multidimensional CFD – particle model (CLOUD-FPM). In the model the coupled fields of gas/vapour species, temperature, flow velocity and particle properties were computed to investigate the tank's mixing state and mixing times. Simulation results show that the mixing state of the tank's contents largely depends on the characteristics of the mixing fans and a 1-fan configuration, as used in first experiments, may not be sufficient to ensure a homogeneously mixed chamber. To mix the tank properly, 2 fans are necessary. The 1/e response times for instantaneous changes of wall temperature and saturation ratio inside the chamber were found to be in the order of few minutes. Particle nucleation and growth was also simulated and particle number size distribution properties of the freshly nucleated particles (particle number, mean size, standard deviation of the assumed log-normal distribution) were found to be mixed over the tank's volume similar to the gas species.
Estudiosos dos campos da Educação, da Linguística Aplicada e da Formação de Professores de Línguas insistem hoje na grande importância da inclusão de Tecnologias de Informação e Comunicação (TICs) na formação inicial, bem como na necessidade de promover o desenvolvimento do pensamento crítico-reflexivo dos futuros professores. Tomando como pressupostos teóricos estudos acerca das características da sociedade de informação, dos ambientes virtuais e da formação de professores, este trabalho tem como objetivo discutir possibilidades oferecidas pela plataforma Moodle de aprendizagem na formação inicial de professores de alemão. Para tanto, apresentaremos diferentes formas de uso de ambientes virtuais e de ferramentas neles disponíveis, que demonstraram ser de grande valor no processo de formação de licenciandos, tanto em língua alemã, quanto durante suas práticas iniciais. As experiências apontam para um valor inestimável de ambientes virtuais no acompanhamento de licenciandos no processo de aprendizagem da língua e nas primeiras experiências com a docência.
O presente artigo analisa o conceito de esclarecimento em Horkheimer, Adorno e Freud. Para tanto, traça um paralelo entre duas das mais representativas obras destes autores no âmbito da crítica cultural. Trata-se, respectivamente, dos textos O Conceito de Esclarecimento e O Futuro de uma Ilusão. Embora uma primeira leitura dos trabalhos citados possa sugerir diferentes perspectivas teóricas, aposta-se aqui na sua complementaridade em defesa de uma utilização mais adequada do pensamento conceitual.
Sob uma perspectiva crítica, são abordadas neste artigo, imagens sobre a língua alemã e seus falantes, apresentadas por estudantes universitários brasileiros, interessados em aprender esse idioma ou engajados em estágio inicial de sua aprendizagem. O propósito é discutir evidências de imagens estereotipadas, bem como refletir sobre possíveis decorrências dessas imagens no/para o processo de ensino-aprendizagem da língua, buscando, com isso, apontar a importância de se considerar como objetivo relevante no ensino de alemão, a necessidade de um percurso de "desestranhamento" do idioma, por meio de enfoque metodológico orientado para auxiliar os aprendizes no processo de desenvolvimento de competência intercultural. Tais reflexões têm como base pressupostos teóricos como as noções de "outro" e de "próprio", as concepções de competência intercultural e de ensino intercultural, e resultados obtidos em pesquisa desenvolvida no campo de ensino e aprendizagem de língua estrangeira (alemão).
Rezension zu Silvana Vranić: Govori sjeverozapadnoga makrosustava na otoku Pagu, 2. MORFOLOGIJA. Rijeka: Matica hrvatska Ogranak Novalja, Filozofski fakultet Sveučilišta u Rijeci, 2011, 235 S.