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Mumien im Film
(2016)
Inhalt:
Hans J. Wulff: Von lebenden Toten, der Verfluchung der Lebenden und später Rache: Die Mumien der Filmgeschichte.
Hans J. Wulff: Mumien im Film. Filmographie.
Fiktionale Filme, Serien und Serienfolgen.
Dokumentationen, Dokumentarfilme, Reality-TV-Sendungen.
Eismumien im Film.
Prähistorische Moorleichen.
Die Mumienfilme der Universal Pictures (1940–1955).
Die Mumienfilme der Hammer Film Productions.
Die mexikanischen Mumienfilme.
Adaptionen von Bram Stokers Roman Jewel of Seven Stars.
Hans J. Wulff: Mumien im Film. Bibliographie.
Missionsfilme
(2016)
Inhalt:
Ludger Kaczmarek / Hans J. Wulff: Missionsfilm.
Missionsfilm. Ein filmo-bibliographisches Verzeichnis. Kompiliert von Gerlinde Waz mit Ergänzungen durch Hans J. Wulff.
1. Filmographie des deutschen Missionsfilms nach dem Ersten Weltkrieg (im Alphabet der Titel).
2. Chronologischer Index der Missionsfilme.
3. Bibliographie zum Missionsfilm.
Within the family of NADPH oxidases, NOX4 is unique as it is predominantly localized in the endoplasmic reticulum, has constitutive activity, and generates hydrogen peroxide (H2O2). We hypothesize that these features are consequences of a so far unidentified NOX4-interacting protein. Two-dimensional blue native (BN) electrophorese combined with SDS-PAGE yielded NOX4 to reside in macromolecular complexes. Interacting proteins were screened by quantitative SILAC (stable isotope labeling of amino acids in cell culture) co-immunoprecipitation (Co-IP) in HEK293 cells stably overexpressing NOX4. By this technique, several interacting proteins were identified with calnexin showing the most robust interaction. Calnexin also resided in NOX4-containing complexes as demonstrated by complexome profiling from BN-PAGE. The calnexin NOX4 interaction could be confirmed by reverse Co-IP and proximity ligation assay, whereas NOX1, NOX2, or NOX5 did not interact with calnexin. Calnexin deficiency as studied in mouse embryonic fibroblasts from calnexin(-/-)mice or in response to calnexin shRNA reduced cellular NOX4 protein expression and reactive oxygen species formation. Our results suggest that endogenous NOX4 forms macromolecular complexes with calnexin, which are needed for the proper maturation, processing, and function of NOX4 in the endoplasmic reticulum.
Hepatitis C virus (HCV) substantially affects lipid metabolism, and remodeling of sphingolipids appears to be essential for HCV persistence in vitro. The aim of the current study is the evaluation of serum sphingolipid variations during acute HCV infection. We enrolled prospectively 60 consecutive patients with acute HCV infection, most of them already infected with human immunodeficiency virus (HIV), and serum was collected at the time of diagnosis and longitudinally over a six-month period until initiation of antiviral therapy or confirmed spontaneous clearance. Quantification of serum sphingolipids was performed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Spontaneous clearance was observed in 11 out of 60 patients (18.3%), a sustained viral response (SVR) in 43 out of 45 patients (95.5%) receiving an antiviral treatment after follow-up, whereas persistence of HCV occurred in six out of 60 patients (10%). C24-ceramide (C24-Cer)-levels increased at follow-up in patients with spontaneous HCV eradication (p < 0.01), as compared to baseline. Sphingosine and sphinganine values were significantly upregulated in patients unable to clear HCV over time compared to patients with spontaneous clearance of HCV infection on follow-up (p = 0.013 and 0.006, respectively). In summary, the persistence of HCV after acute infection induces a downregulation of C24Cer and a simultaneous elevation of serum sphingosine and sphinganine concentrations.