Refine
Keywords
- MRSA (1)
- Photorhabdus (1)
- Staphylococcus aureus (1)
- azaindole (1)
- azides (1)
- click chemistry (1)
- electrophilic natural products (1)
- enrichment (1)
- epoxides (1)
- fluorescent dye (1)
Institute
- Biowissenschaften (2)
- Medizin (1)
- Solid-phase enrichment and analysis of electrophilic natural products (2017)
- In search for new natural products, which may lead to the development of new drugs for all kind of applications, novel methods are needed. Here we describe the identification of electrophilic natural products in crude extracts via their reactivity against azide as a nucleophile followed by their subsequent enrichment using a cleavable azide-reactive resin (CARR). Using this approach, natural products carrying epoxides and α,β-unsaturated enones as well as several unknown compounds were identified in crude extracts from entomopathogenic Photorhabdus bacteria.
- Synthesis and SAR of the antistaphylococcal natural product nematophin from Xenorhabdus nematophila (2019)
- The repeated and improper use of antibiotics had led to an increased number of multiresistant bacteria. Therefore, new lead structures are needed. Here, the synthesis and an expanded structure–activity relationship of the simple and antistaphylococcal amide nematophin from Xenorhabdus nematophila and synthetic derivatives are described. Moreover, the synthesis of intrinsic fluorescent derivatives, incorporating azaindole moieties was achieved for the first time.
