- Kinetic energy flow in Nb(400 A MeV) + Nb: evidence for hydrodynamic compression of nuclear matter (1984)
- A kinetic-energy—flow analysis of multiplicity-selected collisions of 93Nb(Elab=400A MeV)+93Nb is performed on the basis of the nuclear fluid dynamical model. The effects of finite particle numbers on the flow tensor are explicitly taken into account. Strong sidewards peaks are predicted in dN/dcosθF, the distribution of event by event flow angles. This is in qualitative agreement with recent data from the "Plastic Ball" electronic detection system. Cascade simulations fail to reproduce the data.
- Viscous fluid dynamical calculation of the reaction 12C(85 MeV/nucleon) + 197Au (1983)
- Proton spectra have been calculated for the reaction 12C(85 MeV/nucleon) + 197Au using a three-dimensional hydrodynamical model with viscosity and thermal conductivity and final thermal breakup. The theoretical results are compared to recent data. It is shown that the predicted flow effects are not observable as a result of the impact parameter averaging inherent in the inclusive proton spectra. In contrast, angular distributions of medium mass nuclei (A>3) in nearly central collisions can provide signatures for flow effects.
- Phase transition of the nucleon-antinucleon plasma in a relativistic mean-field theory (1985)
- Studying Walecka's mean-field theory we find that one can reproduce the observed binding energy and density of nuclear matter within experimental precision in an area characterized by a line in the coupling-constant plane. A part of this line defines systems which exhibit a phase transition around Tc~200 MeV for zero baryon density. The rest corresponds to such systems where the phase transition is absent; in that case a peak appears in the specific heat around T~200 MeV. We interpret these results as indicating that the hadron phase of nuclear matter alone indicates the occurrence of an abrupt change in the bulk properties around ρV~0 and T~200 MeV.
- Event-by-event analysis : possible testing ground for the nuclear matter equation of state (1984)
- Intranuclear cascade calculations and fluid dynamical predictions of the kinetic energy flow are compared for collisions of 40Ca + 40Ca and 238U + 238U. The aspect ratio, R13, as obtained from the global analysis, is independent of the bombarding energy for the intranuclear cascade model. Fluid dynamics, on the other hand, predicts a dramatic increase of R13 at medium energies Elab≲200 MeV/nucleon. In fact, R13(Elab) directly reflects the incompressibility of the nuclear matter and can be used to extract the nuclear equation of stat at high densities. Distortions of the flow tensor due to few nucleon scattering are analyzed. Possible procedures to remove this background from experimental data are discussed.
- Phase structure of excited baryonic matter in the relativistic mean field theory (1987)
- We analyze the phase structure of the nonlinear mean-field meson theory of baryonic matter (nucleons plus delta resonances). Depending on the choice of the coupling constants, we find three physically distinct phase transitions in this theory: a nucleonic liquid-gas transition in the low temperature, Tc<20 MeV, low density, ρ≃0.5ρ0, regime, a high-temperature (T≃150 MeV) finite density transition from a gas of massive hadrons to a nearly massless baryon, antibaryon plasma, and, third, a strong phase transition from the nucleonic fluid to a resonance-dominated ‘‘delta-matter’’ isomer at ρ>2ρ0 and Tc<50 MeV. All three phase transitions are of first order. It is shown that the occurrence of these different phase transitions depends critically on the coupling constants. Since the production of pions also depends strongly on the coupling constants, it is seen that the equation of state cannot be derived unambiguously from pion data.
- Cytokine-Regulated GADD45G Induces Differentiation and Lineage Selection in Hematopoietic Stem Cells (2014)
- The balance of self-renewal and differentiation in long-term repopulating hematopoietic stem cells (LT-HSC) must be strictly controlled to maintain blood homeostasis and to prevent leukemogenesis. Hematopoietic cytokines can induce differentiation in LT-HSCs; however, the molecular mechanism orchestrating this delicate balance requires further elucidation. We identified the tumor suppressor GADD45G as an instructor of LT-HSC differentiation under the control of differentiation-promoting cytokine receptor signaling. GADD45G immediately induces and accelerates differentiation in LT-HSCs and overrides the self-renewal program by specifically activating MAP3K4-mediated MAPK p38. Conversely, the absence of GADD45G enhances the self-renewal potential of LT-HSCs. Videomicroscopy-based tracking of single LT-HSCs revealed that, once GADD45G is expressed, the development of LT-HSCs into lineage-committed progeny occurred within 36 hr and uncovered a selective lineage choice with a severe reduction in megakaryocytic-erythroid cells. Here, we report an unrecognized role of GADD45G as a central molecular linker of extrinsic cytokine differentiation and lineage choice control in hematopoiesis.