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- Minimal information for studies of extracellular vesicles 2018 (MISEV2018) : a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines (2018)
- Clotilde Théry Kenneth W. Witwer Elena Aikawa Maria Jose Alcaraz Johnathon D. Anderson Ramaroson Andriantsitohaina Anna Antoniou Tanina Arab Fabienne Archer Georgia K. Atkin-Smith D. Craig Ayre Jean-Marie Bach Daniel Bachurski Hossein Baharvand Leonora Balaj Shawn Baldacchino Natalie N. Bauer Amy A. Baxter Mary Bebawy Carla Beckham Apolonija Bedina Zavec Abderrahim Benmoussa Anna C. Berardi Paolo Bergese Ewa Bielska Cherie Blenkiron Sylwia Bobis-Wozowicz Eric Boilard Wilfrid Boireau Antonella Bongiovanni Francesc E. Borràs Steffi Bosch Chantal M. Boulanger Xandra Breakefield Andrew M. Breglio Meadhbh Aín Brennan David R. Brigstock Alain Brisson Marike L. D. Broekman Jacqueline F. Bromberg Paulina Bryl-Gorecka Shilpa Buch Amy H. Buck Dylan Burger Sara Busatto Dominik Buschmann Benedetta Bussolati Edit I. Buzás James Bryan Byrd Giovanni Camussi David R. F. Carter Sarah Caruso Lawrence W. Chamley Yu-Ting Chang Chihchen Chen Shuai Chen Lesley Cheng Andrew R. Chin Aled Clayton Stefano P. Clerici Alex Cocks Emanuele Cocucci Robert J. Coffey Anabela Cordeiro-da-Silva Yvonne Couch Frank A. W. Coumans Beth Coyle Rossella Crescitelli Miria Ferreira Criado Crislyn D’Souza-Schorey Saumya Das Amrita Datta Chaudhuri Paola de-Candia Eliezer F. De Santana Olivier De Wever Hernando A. del Portillo Tanguy Demaret Sarah Deville Andrew Devitt Bert Dhondt Dolores Di Vizio Lothar C. Dieterich Vincenza Dolo Ana Paula Dominguez Rubio Massimo Dominici Mauricio R. Dourado Tom A. P. Driedonks Filipe V. Duarte Heather M. Duncan Ramon Marc Eichenberger Karin Ekström Samir El Andaloussi Celine Elie-Caille Uta Erdbrügger Juan M. Falcón-Pérez Farah Fatima Jason E. Fish Miguel Flores-Bellver András Försönits Annie Frelet-Barrand Fabia Fricke Gregor Fuhrmann Susanne Gabrielsson Ana Gámez-Valero Chris Gardiner Kathrin Gärtner Raphael Gaudin Yong Song Gho Bernd Giebel Caroline Gilbert Mario Gimona Ilaria Giusti Deborah C. I. Goberdhan André Görgens Sharon M. Gorski David W. Greening Julia Christina Groß Alice Gualerzi Gopal N. Gupta Dakota Gustafson Aase Handberg Réka Ágnes Haraszti Paul Harrison Hargita Hegyesi An Hendrix Andrew F. Hill Fred H. Hochberg Karl F. Hoffmann Beth Holder Harry Holthofer Baharak Hosseinkhani Guoku Hu Yiyao Huang Veronica Huber Stuart Hunt Ahmed Gamal-Eldin Ibrahim Tsuneya Ikezu Jameel M. Inal Mustafa Isin Alena Ivanova Hannah K. Jackson Soren Jacobsen Steven M. Jay Muthuvel Jayachandran Guido Jenster Lanzhou Jiang Suzanne M. Johnson Jennifer C. Jones Ambrose Jong Tijana Jovanovic-Talisman Stephanie Jung Raghu Kalluri Shin-ichi Kano Sukhbir Kaur Yumi Kawamura Evan T. Keller Delaram Khamari Elena Khomyakova Anastasia Khvorova Peter Kierulf Kwang Pyo Kim Thomas Kislinger Mikael Klingeborn David J. Klinke Miroslaw Kornek Maja M. Kosanović Árpád Ferenc Kovács Eva-Maria Krämer-Albers Susanne Krasemann Mirja Krause Igor V. Kurochkin Gina D. Kusuma Sören Kuypers Saara Laitinen Scott M. Langevin Lucia R. Languino Joanne Lannigan Cecilia Lässer Louise C. Laurent Gregory Lavieu Elisa Lázaro-Ibáñez Soazig Le Lay Myung-Shin Lee Yi Xin Fiona Lee Debora S. Lemos Metka Lenassi Aleksandra Leszczynska Isaac T. S. Li Ke Liao Sten F. Libregts Erzsebet Ligeti Rebecca Lim Sai Kiang Lim Aija Linē Karen Linnemannstöns Alicia Llorente Catherine Ann Lombard Magdalena J. Lorenowicz Ákos M. Lörincz Jan Lötvall Jason Lovett Michelle C. Lowry Xavier Loyer Quan Lu Barbara Lukomska Taral Rameshchand Lunavat Sybren L. N. Maas Harmeet Malhi Antonio Marcilla Jacopo Mariani Javier Mariscal Elena S. Martens-Uzunova Lorena Martin-Jaular M. Carmen Martinez Vilma Regina Martins Mathilde Mathieu Suresh Mathivanan Marco Maugeri Lynda K. McGinnis Mark J. McVey David G. Meckes Katie Meehan Inge Mertens Valentina R. Minciacchi Andreas Möller Malene Møller Jørgensen Aizea Morales-Kastresana Jess Morhayim François Mullier Maurizio Muraca Luca Musante Veronika Mussack Dillon C. Muth Kathryn H. Myburgh Tanbir Najrana Muhammad Nawaz Irina Nazarenko Peter Nejsum Christian Neri Tommaso Neri Rienk Nieuwland Leonardo Nimrichter John P. Nolan Esther N. M. Nolte-’t Hoen Nicole Noren Hooten Lorraine O’Driscoll Tina O’Grady Ana O’Loghlen Takahiro Ochiya Martin Olivier Alberto Ortiz Luis A. Ortiz Xabier Osteikoetxea Ole Østergaard Matias Ostrowski Jaesung Park Dirk Michiel Pegtel Hector Peinado Francesca Perut Michael Pfaffl Donald G. Phinney Bartijn C. H. Pieters Ryan Charles Pink David S. Pisetsky Elke Pogge von Strandmann Iva Polakovicova Ivan K. H. Poon Bonita H. Powell Ilaria Prada Lynn Pulliam Peter Quesenberry Annalisa Radeghieri Robert L. Raffai Stefania Raimondo Janusz Rak Marcel I. Ramirez Graça Raposo Morsi S. Rayyan Neta Regev-Rudzki Franz Lennard Ricklefs Paul D. Robbins David D. Roberts Silvia C. Rodrigues Eva Rohde Sophie Rome Kasper M. Rouschop Aurelia Rughetti Ashley E. Russell Paula Saá Susmita Sahoo Edison Salas-Huenuleo Catherine Sánchez Julie A. Saugstad Meike J. Saul Raymond M. Schiffelers Raphael Schneider Tine Hiorth Schøyen Aaron Scott Eriomina Shahaj Shivani Sharma Olga Shatnyeva Faezeh Shekari Ganesh Vilas Shelke Ashok K. Shetty Kiyotaka Shiba Pia R.-M. Siljander Andreia M. Silva Agata Skowronek Orman L. Snyder Rodrigo Pedro Soares Barbara W. Sódar Carolina Soekmadji Javier Sotillo Philip D. Stahl Willem Stoorvogel Shannon L. Stott Erwin F. Strasser Simon Swift Hidetoshi Tahara Muneesh Tewari Kate Timms Swasti Tiwari Rochelle Tixeira Mercedes Tkach Wei Seong Toh Richard Tomasini Ana Claudia Torrecilhas Juan Pablo Tosar Vasilis Toxavidis Lorena Urbanelli Pieter Vader Bastiaan Wilhelmus Maria van Balkom Susanne G. van der Grein Jan Van Deun Martijn J. C. van Herwijnen Kendall Van Keuren-Jensen Guillaume van Niel Martin E. van Royen Andre J. van Wijnen M. Helena Vasconcelos Ivan J. Vechetti Tiago D. Veit Laura J. Vella Émilie Velot Frederik Verweij Beate Vestad Jose Luis Viñas Tamás Visnovitz Krisztina V. Vukman Jessica Wahlgren Dionysios C. Watson Marca H. M. Wauben Alissa Weaver Jason P. Webber Viktoria Weber Ann M. Wehman Daniel J. Weiss Joshua A. Welsh Sebastian Wendt Åsa M. Wheelock Zoltán Wiener Leonie Witte Joy Wolfram Angeliki Xagorari Patricia Xander Jing Xu Xiaomei Yan María Yáñez-Mó Hang Yin Yuana Yuana Valentina Zappulli Jana Zarubova Vytautas Žėkas Jian-ye Zhang Zezhou Zhao Lei Zheng Alexander R. Zheutlin Antje Maria Zickler Pascale Zimmermann Angela M. Zivkovic Davide Zocco Ewa K. Zuba-Surma
- The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranous structures, called exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and many other names. However, specific issues arise when working with these entities, whose size and amount often make them difficult to obtain as relatively pure preparations, and to characterize properly. The International Society for Extracellular Vesicles (ISEV) proposed Minimal Information for Studies of Extracellular Vesicles (“MISEV”) guidelines for the field in 2014. We now update these “MISEV2014” guidelines based on evolution of the collective knowledge in the last four years. An important point to consider is that ascribing a specific function to EVs in general, or to subtypes of EVs, requires reporting of specific information beyond mere description of function in a crude, potentially contaminated, and heterogeneous preparation. For example, claims that exosomes are endowed with exquisite and specific activities remain difficult to support experimentally, given our still limited knowledge of their specific molecular machineries of biogenesis and release, as compared with other biophysically similar EVs. The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities. Finally, a checklist is provided with summaries of key points.
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