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- Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa (2017)
- Anorexia nervosa (AN) is a complex neuropsychiatric disorder presenting with dangerously low body weight, and a deep and persistent fear of gaining weight. To date, only one genome-wide significant locus associated with AN has been identified. We performed an exome-chip based genome-wide association studies (GWAS) in 2158 cases from nine populations of European origin and 15 485 ancestrally matched controls. Unlike previous studies, this GWAS also probed association in low-frequency and rare variants. Sixteen independent variants were taken forward for in silico and de novo replication (11 common and 5 rare). No findings reached genome-wide significance. Two notable common variants were identified: rs10791286, an intronic variant in OPCML (P=9.89 × 10−6), and rs7700147, an intergenic variant (P=2.93 × 10−5). No low-frequency variant associations were identified at genome-wide significance, although the study was well-powered to detect low-frequency variants with large effect sizes, suggesting that there may be no AN loci in this genomic search space with large effect sizes.
- Developmentally adapted cognitive processing therapy for adolescents and young adults with PTSD symptoms after physical and sexual abuse : study protocol for a randomized controlled trial (2014)
- Background: Although childhood sexual and/or physical abuse (CSA/CPA) is known to have severe psychopathological consequences, there is little evidence on psychotherapeutic interventions for adolescents and young adults suffering from post-traumatic stress disorder (PTSD). Equally sparse are data on moderators of treatment response on PTSD-related epigenetic changes, health care costs and loss of productivity, alterations in cognitive processing, and on how successful interventions affect all of these factors. Early treatment may prevent later (co)morbidity. In this paper, we present a study protocol for the evaluation of a newly developed psychotherapeutic manual for PTSD after CSA/CPA in adolescents and young adults – the Developmentally Adapted Cognitive Processing Therapy (D-CPT). Methods/design: In a multicenter randomized controlled trial (RCT) D-CPT is compared to treatment as usual (TAU). A sample of 90 adolescent outpatients aged 14 to 21 years will be randomized to one of these conditions. Four assessments will be carried out at baseline, at end of treatment, and 3 and 6 months after end of therapy. Each time, patients will be assessed via clinical interviews and a wide range of questionnaires. In addition to PTSD symptoms and comorbidities, we will evaluate moderators of treatment response, epigenetic profiles, direct and indirect costs of this disorder, and neurophysiological processing of threat cues in PTSD and their respective changes in the course of these two treatments (D-CPT and TAU). Discussion: The study will provide new insights in the understudied field of PTSD in adolescents and young adults. A newly developed intervention will be evaluated in this therapeutically underserved population. Results will provide data on treatment efficacy, direct and indirect treatment costs, as well as on associations of treatment outcome and PTSD intensity both to epigenetic profiles and to the neurobiological processing of threat cues. Besides, they will help to learn more about the psychopathology and possible new objective correlates of PTSD. Trial registration: Germanctr.de identifier: DRKS00004787.
- Jüdische Bibliotheken in Frankfurt am Main : vom Anfang des 19. Jahrhunderts bis 1938 (1987)
- Außer bedeutenden Privatbibliotheken und der berühmten Rothschildbibliothek gab es in Frankfurt mehrere jüdische Bibliotheken,die sich vorallem die Aufgabe stellten, jüdisches und allgemeines Wissen an eine breitere Leserschicht zu vermitteln. Zu Beginn des 19. Jahrhunderts leisteten die vier jüdischen Lesekabinette ihren Beitrag zur Unterstützung der Frankfurter Juden auf ihrem Weg zur bürgerlichen Gleichberechtigung. Gegen Ende des 19. Jahrhunderts war als Folge einer raschen Assimilation bei vielen ein Mangel an jüdischer Bildung festzustellen. Dem entgegenzuwirken engagierten sich Bildungs- und Jugendvereine sowie die Frankfurt-Loge unter anderem durch Errichtung von Bibliotheken. Zur Zeit der Bücherhallenbewegung entstand die Jüdische Bibliothek und Lesehalle, die von einem Bibliotheksverein getragen wurde. Sie wurde später ein Teil der neuen Gemeindebibliothek, die mehrere Bibliotheken in sich vereinigte. Diese Bibliothek war eine leistungsfähige Bibliothek,die populären und wissenschaftlichen Ansprüchen genügte. Sie wurde am 9. November 1938 von den Nationalsozialisten zerstört.
