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The role of peroxisome proliferator-activated receptor gamma during sepsis-induced lymphopenia
(2011)
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Martina Schmidt
- Sepsis is one of the most common diseases on intensive care units all over the
world and accounts there for the highest mortality rate. One of the hallmarks of
sepsis is an accelerated T-cell apoptosis, resulting in a compromised immune
state with the inability to eradicate pathogens. This promotes organ damage or
even organ failure. A multiple organ dysfunction evolves, which often ends up in
septic shock and death. Recently, it was shown that severe T-cell depletion
correlates with sepsis mortality. When inhibiting T-cell apoptosis, an increased
mouse survival was observed in experimental sepsis. ...
