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In this paper we describe SOBA, a sub-component of the SmartWeb multi-modal dialog system. SOBA is a component for ontologybased information extraction from soccer web pages for automatic population of a knowledge base that can be used for domainspecific question answering. SOBA realizes a tight connection between the ontology, knowledge base and the information extraction component. The originality of SOBA is in the fact that it extracts information from heterogeneous sources such as tabular structures, text and image captions in a semantically integrated way. In particular, it stores extracted information in a knowledge base, and in turn uses the knowledge base to interpret and link newly extracted information with respect to already existing entities.
This demo abstract describes the SmartWeb Ontology-based Information Extraction System (SOBIE). A key feature of SOBIE is that all information is extracted and stored with respect to the SmartWeb ontology. In this way, other components of the systems, which use the same ontology, can access this information in a straightforward way. We will show how information extracted by SOBIE is visualized within its original context, thus enhancing the browsing experience of the end user.
The research performed in the DeepThought project aims at demonstrating the potential of deep linguistic processing if combined with shallow methods for robustness. Classical information retrieval is extended by high precision concept indexing and relation detection. On the basis of this approach, the feasibility of three ambitious applications will be demonstrated, namely: precise information extraction for business intelligence; email response management for customer relationship management; creativity support for document production and collective brainstorming. Common to these applications, and the basis for their development is the XML-based, RMRS-enabled core architecture framework that will be described in detail in this paper. The framework is not limited to the applications envisaged in the DeepThought project, but can also be employed e.g. to generate and make use of XML standoff annotation of documents and linguistic corpora, and in general for a wide range of NLP-based applications and research purposes.
In the area of the Modern Greek verb, phenomena which consistently appear are headmarking, many potential slots before and/or after the verb root, noun and adverb incorporation, addition of adverbial elements by means of affixes, a large inventory of bound morphemes, verbal words as minimal sentences, etc. These features relate Modern Greek to polysynthesis. The main bulk of this paper is dedicated to the comparison of affixal and incorporation patterns between Modern Greek and the polysynthetic languages Abkhaz, Cayuga, Chukchi, Mohawk, and Nahuatl. Ultimately, a typological outlook for Modern Greek is proposed.
Cancer cells, including leukemic cells, can react to therapeutic treatment by altering their metabolic phenotype (“metabolic reprogramming”) to keep their accelerated proliferative state, eventually becoming resistant to the treatment. There is an increasing amount of evidence indicating that metabolic reprogramming is one of the key mechanisms of acquisition of drug resistance by cancer cells. In agreement, several metabolic studies targeting leukaemia and specifically acute myeloid leukaemia (AML) and chronic myeloid leukaemia (CML), have been conducted over the last decades. However, there is still a lack of understanding the metabolic features of both AML and CML leukaemia specially in the acquisition of drug resistance, that is needed for unveiling novel and effective treatments for resistant and non-resistant patients. Therefore, the main objective of this thesis was to investigate the rewiring of cell metabolism occurring in the process of acquisition of resistance to conventional therapeutic treatments in AML and CML malignancies. Next, by revealing this metabolic rewiring, we intended to highlight potential metabolic and non-metabolic targets that could be exploited to overcome resistance to treatments. To this end, we have performed a comprehensive and comparative multi-OMIC study to analyse the links between the metabolic reprogramming and the resistance acquisition of THP-1 and HL-60 AML cell models sensitive or resistant to cytarabine (AraC) and doxorubicin (Dox), and of KU812 CML cell model sensitive or resistant to imatinib, all under normoxic (21% O2) and hypoxic (1% O2) conditions. The results of this thesis are divided into two chapters. On the one hand, in Chapter 1, the multi-OMIC study performed in AML parental and resistant cells unveiled that the acquisition of AraC resistance causes the reprogramming of the glucose metabolism of THP-1 and HL-60 cells by increasing the glycolytic flux whereas it is not associated with an alteration in the mitochondrial respiration. Moreover, our results also exhibited a possible disfunction of ETC complex I as well as alterations in glutamine and serine-glycine-1C metabolism in AML cells that display a more active mitochondrial metabolism. Moreover, we have also identified that the acquisition of Dox resistance causes alterations in the glucose and amino acid metabolism. Importantly, we have observed an important loss of mitochondrial respiration capacity of AML cells resistant to Dox chemotherapeutic drug, which constitutes a potential metabolic vulnerability that can be exploited for the treatment of AML patients resistant to Dox. On the other hand, in Chapter 2 is shown that the acquisition of imatinib resistance causes the reprogramming of glucose metabolism by enhancing the glycolytic flux, PPP, and glycogen metabolism, thus highlighting these metabolic pathways as potential metabolic weaknesses of KU812 cells resistant to imatinib. Moreover, we have observed a high metabolic plasticity of KU812 cells resistant to imatinib which includes the orchestration of many metabolic routes associated with the amino acid metabolism. Importantly, the CML multi-OMIC study has also unveiled an enhanced mitochondrial respiration capacity, which constitutes another potential vulnerability that can be exploited to overcome imatinib resistance. Finally, both AML and CML multi-OMIC studies have allowed us to propose and/or validate different metabolic and non-metabolic targets. In this regard, in this thesis we have identified and validated a battery of single-hit inhibitions that were able to reduce the cell viability of both parental and resistant AML and CML cells. Finally, we have confirmed that the repurposing of Dox chemotherapeutic drug counteracts the imatinib resistance in the KU812 cells resistant to imatinib.
We present an architecture for the integration of shallow and deep NLP components which is aimed at flexible combination of different language technologies for a range of practical current and future applications. In particular, we describe the integration of a high-level HPSG parsing system with different high-performance shallow components, ranging from named entity recognition to chunk parsing and shallow clause recognition. The NLP components enrich a representation of natural language text with layers of new XML meta-information using a single shared data structure, called the text chart. We describe details of the integration methods, and show how information extraction and language checking applications for realworld German text benefit from a deep grammatical analysis.
Four new species of the genus Sokoloviana (Pterolichoidea; Ptiloxenidae) from waders suborder Charadrii (Charadriiformes) are described: Sokoloviana cornuta sp. nov. from the Banded Stilt, Cladorhynchus leucocephalus; Sokoloviana ibidorhynchae sp. nov. from the Ibis-bill, Ibidorhyncha strutersi; Sokoloviana chilensis sp. nov. from the Southern Lapwing, Vanellus chilensis and Sokoloviana vanelli sp. nov. from the Red-wattled Lapwing, Vanellus indicus atronuchalis. A key to all described species is given.
A new genus and species of armored scale insect (Hemiptera: Diaspididae), Protomorgania koebelei.
Dooley and Evans, is described and illustrated from specimens collected by Albert Koebele on Pittosporum sp.
(Pittosporaceae) in Australia around the year 1900. A key to the genera of armored scale insects similar to Protomorgania
and known to occur in Australia is provided.
In the last two decades Philippine languages, and of these especially Tagalog, have acquired a prominent place in linguistic theory. A central role in this discussion was played by two papers written by Schachter (1976 and 1977), who was inspired by Keenan's artcle on the subject from 1976. The most recent contributions on this topic have been from de Wolff (1988) and Shibatani (1988), both of which were published in a collection of essays, edited by Shibatani, with the title Passive and Voice. These works, and several works in-between, deal with the focus system specific to Philippine languages. The main discussion centers around the fact that Philippine languages contain a basic set of 5 to 7 affix focus forms. Their exact number varies not only in the secondary literature, but in the primary sources, i.e. Tagalog grammars, as well, where considerable differences in the number of affix focus forms can be found. All of these works, however, do agree on one point: the Philippine focus system basica1ly consists of agent, patient (=goal or object), benefactive, locative, and instrumental affix forms. Schachter/Otanes (1972) list a number of further forms, and in Drossard (1983 and 1984) we tried to show (in an attempt similar to those of Sapir 1917 and Klimov 1977) that the main criterion for a systematization of the Philippine focus system consists in the difference between the active and stative domains, an attempt which in our opinion was largely misunderstood (cf. the brief remarks in Shibatani (1988) and de Wolff (1988). The present paper is thus, on the one hand, an attempt to repeat and clarify our earlier position, and on the other, a further step towards such a systematization. A first step in this direction was an article on resultativity in Tagalog from 1991. In the present paper this approach will be extended to reciprocity. In the process we will show that it is valid to make a distinction between an active (=controlled action) vs. a stative (=limited controlled action) domain. First, however, we will take a brief look at what makes up the active and stative voice systems.
When, some two centuries ago, German Romantics turned their backs on modernity – industrialisation, urbanisation, commerce and secularisation – they turned to ancient India. For them, India exemplified the primordial unity of mankind with this and the afterworld. For sections of the emerging nationalist movement in Germany, found the deployment of India handy to question the cultural hegemony, and eventually break the political dominance, of France. They tried to surpass the French, who claimed the ancient Roman heritage, by claiming an even older heritage for the Germans. Friedrich Schlegel for example suggested that the German language, and not the French, stood in unbroken continuity with ancient Sanskrit. For Romantics such as he, Sanskrit, the oldest surviving Indo-European language, was closest to the language of original divine revelation. This lead Schlegel to romanticise India in a way that stood in marked contrast to the Orientalist clichés current in other parts of Europe at the time. For him, the link between Sanskrit and German made Germany the true oriental self of Europe. The importance of this particular representation of India for the German national movement is underlined by the great number of university chairs that sprang up in the course of the nineteenth century: twenty two in Germany as opposed to only three in the United Kingdom. This paper explores the particular kind of ‘inverse’ Orientalism of the Germans in the context of its recent post-colonial critique.