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- Descriptional complexity of cellular automata and decidability questions (2001)
- We study the descriptional complexity of cellular automata (CA), a parallel model of computation. We show that between one of the simplest cellular models, the realtime-OCA. and "classical" models like deterministic finite automata (DFA) or pushdown automata (PDA), there will be savings concerning the size of description not bounded by any recursive function, a so-called nonrecursive trade-off. Furthermore, nonrecursive trade-offs are shown between some restricted classes of cellular automata. The set of valid computations of a Turing machine can be recognized by a realtime-OCA. This implies that many decidability questions are not even semi decidable for cellular automata. There is no pumping lemma and no minimization algorithm for cellular automata.

- Minimizing finite automata is computationally hard (2002)
- It is known that deterministic finite automata (DFAs) can be algorithmically minimized, i.e., a DFA M can be converted to an equivalent DFA M' which has a minimal number of states. The minimization can be done efficiently [6]. On the other hand, it is known that unambiguous finite automata (UFAs) and nondeterministic finite automata (NFAs) can be algorithmically minimized too, but their minimization problems turn out to be NP-complete and PSPACE-complete [8]. In this paper, the time complexity of the minimization problem for two restricted types of finite automata is investigated. These automata are nearly deterministic, since they only allow a small amount of non determinism to be used. On the one hand, NFAs with a fixed finite branching are studied, i.e., the number of nondeterministic moves within every accepting computation is bounded by a fixed finite number. On the other hand, finite automata are investigated which are essentially deterministic except that there is a fixed number of different initial states which can be chosen nondeterministically. The main result is that the minimization problems for these models are computationally hard, namely NP-complete. Hence, even the slightest extension of the deterministic model towards a nondeterministic one, e.g., allowing at most one nondeterministic move in every accepting computation or allowing two initial states instead of one, results in computationally intractable minimization problems.

- On one-way cellular automata with a fixed number of cells (2003)
- We investigate a restricted one-way cellular automaton (OCA) model where the number of cells is bounded by a constant number k, so-called kC-OCAs. In contrast to the general model, the generative capacity of the restricted model is reduced to the set of regular languages. A kC-OCA can be algorithmically converted to a deterministic finite automaton (DFA). The blow-up in the number of states is bounded by a polynomial of degree k. We can exhibit a family of unary languages which shows that this upper bound is tight in order of magnitude. We then study upper and lower bounds for the trade-off when converting DFAs to kC-OCAs. We show that there are regular languages where the use of kC-OCAs cannot reduce the number of states when compared to DFAs. We then investigate trade-offs between kC-OCAs with different numbers of cells and finally treat the problem of minimizing a given kC-OCA.

- On the descriptional complexity of iterative arrays (2003)
- The descriptional complexity of iterative arrays (lAs) is studied. Iterative arrays are a parallel computational model with a sequential processing of the input. It is shown that lAs when compared to deterministic finite automata or pushdown automata may provide savings in size which are not bounded by any recursive function, so-called non-recursive trade-offs. Additional non-recursive trade-offs are proven to exist between lAs working in linear time and lAs working in real time. Furthermore, the descriptional complexity of lAs is compared with cellular automata (CAs) and non-recursive trade-offs are proven between two restricted classes. Finally, it is shown that many decidability questions for lAs are undecidable and not semidecidable.

- On two-way communication in cellular automata with a fixed number of cells (2003)
- The effect of adding two-way communication to k cells one-way cellular automata (kC-OCAs) on their size of description is studied. kC-OCAs are a parallel model for the regular languages that consists of an array of k identical deterministic finite automata (DFAs), called cells, operating in parallel. Each cell gets information from its right neighbor only. In this paper, two models with different amounts of two-way communication are investigated. Both models always achieve quadratic savings when compared to DFAs. When compared to a one-way cellular model, the result is that minimum two-way communication can achieve at most quadratic savings whereas maximum two-way communication may provide savings bounded by a polynomial of degree k.

- On non-recursive trade-offs between finite-turn pushdown automata (2004)
- It is shown that between one-turn pushdown automata (1-turn PDAs) and deterministic finite automata (DFAs) there will be savings concerning the size of description not bounded by any recursive function, so-called non-recursive tradeoffs. Considering the number of turns of the stack height as a consumable resource of PDAs, we can show the existence of non-recursive trade-offs between PDAs performing k+ 1 turns and k turns for k >= 1. Furthermore, non-recursive trade-offs are shown between arbitrary PDAs and PDAs which perform only a finite number of turns. Finally, several decidability questions are shown to be undecidable and not semidecidable.

- Sublinearly space bounded iterative arrays (2007)
- Iterative arrays (IAs) are a, parallel computational model with a sequential processing of the input. They are one-dimensional arrays of interacting identical deterministic finite automata. In this note, realtime-lAs with sublinear space bounds are used to accept formal languages. The existence of a proper hierarchy of space complexity classes between logarithmic anel linear space bounds is proved. Furthermore, an optimal spacc lower bound for non-regular language recognition is shown. Key words: Iterative arrays, cellular automata, space bounded computations, decidability questions, formal languages, theory of computation

- Neuronal networks for sepsis prediction - the MEDAN project (2004)
- Since the description of sepsis by Schottmüller in 1914, the amount on knowledge available on sepsis and its underlying pathophysiology has substantially increased. Epidemiologic examinations of abdominal septic shock patients show the potential for high risk posed by and the extensive therapy situation in the intensive care unit (ICU) (5). Unfortunately, until now it has not been possible to significantly reduce the mortality rate of septic shock, which is as high as 50-60% worldwide, although PROWESS' results (1) are encouraging. This paper summarizes the main results of the MEDAN project and their medical impacts. Several aspects are already published, see the references. The heterogeneity of patient groups and the variations in therapy strategies is seen as one of the main problems for sepsis trials. In the MEDAN multi-center study of 71 intensive care units in Germany, a group of 382 patients made up exclusively of abdominal septic shock patients who met the consensus criteria for septic shock (3) was analysed. For use within scores or stand-alone experiments variables are often studied as isolated variables, not as a multidimensional whole, e.g. a recent study takes a look at the role thrombocytes play (15). To avoid this limitation, our study compares several established scores (SOFA, APACHE II, SAPS II, MODS) by a multi-dimensional neuronal network analysis. For outcome prediction the data of 382 patients was analysed by using most of the commonly documented vital parameters and doses of medicine (metric variables). Data was collected in German hospitals from 1998 to 2001. The 382 handwritten patient records were transferred to an electronic database giving the amount of 2.5 million data entries. The metric data contained in the database is composed of daily measurements and doses of medicine. We used range and plausibility checks to allow no faulty data in the electronic database. 187 of the 382 patients are deceased (49 %).

- Block reduction for arbitrary norms (1994)
- We generalize the concept of block reduction for lattice bases from l2-norm to arbitrary norms. This extends the results of Schnorr. We give algorithms for block reduction and apply the resulting enumeration concept to solve subset sum problems. The deterministic algorithm solves all subset sum problems. For up to 66 weights it needs in average less then two hours on a HP 715/50 under HP-UX 9.05.