TY  - JOUR
A1  - Leutner, Silke
A1  - Czech, Christian
A1  - Schindowski, Katharina
A1  - Touchet, Nathalie
A1  - Eckert, Anne
A1  - Müller, Walter E.
T1  - Reduced antioxidant enzyme activity in brains of mice transgenic for human presenilin-1 with single or multiple mutations
T2  - Neuroscience letters : an international multidisciplinary journal devoted to the rapid publication of basic research in the neurosciences
N2  - Alzheimer's disease-related mutations in the presenilin-1 gene (PS1) are leading to an elevated production of neurotoxic beta-amyloid 1-42 and may additionally enhance oxidative stress. Here, we provide in vivo evidence indicating that brains of transgenic mice expressing different human Alzheimer-linked PS1 mutations exhibit a reduced activity of two antioxidant enzymes. For this purpose, mice transgenic for human PS1 and for single and multiple PS1 mutations were generated. Mice with multiple PS1 mutations showed a significantly decreased activity of the antioxidant enzymes Cu/Zn superoxide dismutase and glutathione reductase already at an age of 3-4 months. As expected, this effect was less pronounced for the mice with a single PS1 mutation. By contrast, animals bearing normal human PS1 showed significantly elevated enzyme activities relative to non-transgenic littermate controls.
KW  - Alzheimer's disease
KW  - Reactive oxygen species
KW  - Presenilin
KW  - Superoxide dismutase
KW  - Glutathione reductase
KW  - Lipid peroxidation
Y1  - 2006
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/1922
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30-34419
VL  - 292
IS  - 2, Oct. 6
SP  - 87
EP  - 90
PB  - Elsevier Science
CY  - Amsterdam [u.a.]
ER  -