TY - JOUR A1 - Brenneis, Christian A1 - Coste, Ovidiu A1 - Schmidt, Ronald A1 - Angioni, Carlo Federico A1 - Popp, Laura A1 - Nusing, Rolf M. A1 - Becker, Wiebke A1 - Scholich, Klaus A1 - Geisslinger, Gerd T1 - Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice T2 - Journal of cellular and molecular medicine N2 - Cyclooxygenase-2 (COX-2)-dependent prostaglandin (PG) E2 synthesis in the spinal cord plays a major role in the development of inflammatory hyperalgesia and allodynia. Microsomal PGE2 synthase-1 (mPGES-1) isomerizes COX-2-derived PGH2 to PGE2. Here, we evaluated the effect of mPGES-1-deficiency on the noci-ceptive behavior in various models of nociception that depend on PGE2 synthesis. Surprisingly, in the COX-2-dependent zymosan-evoked hyperalgesia model, the nociceptive behavior was not reduced in mPGES-1-deficient mice despite a marked decrease of the spinal PGE2 synthesis. Similarly, the nociceptive behavior was unaltered in mPGES-1-deficient mice in the formalin test. Importantly, spinal cords and primary spinal cord cells derived from mPGES-1-deficient mice showed a redirection of the PGE2 synthesis to PGD2, PGF2α and 6-keto-PGF1α (stable metabolite of PGI2). Since the latter prostaglandins serve also as mediators of noci-ception they may compensate the loss of PGE2 synthesis in mPGES-1-deficient mice. KW - pain KW - spinal cord KW - cyclooxygenase KW - prostaglandin KW - mPGES-1 KW - hyperalgesia Y1 - 2007 UR - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/27922 UR - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-279223 UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822549/ SN - 1582-4934 SN - 1582-1838 N1 - ©2008 The Authors Journal compilation © 2008 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd. This is an Open Access article under the terms of the Creative Commons Attribution Non Commercial License http://creativecommons.org/licenses/by-nc/3.0/ which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. VL - 12 IS - 2 SP - 639 EP - 648 PB - Wiley-Blackwell CY - Hoboken, NJ ER -