TY  - JOUR
A1  - Meckbach, Diana
A1  - Bauer, Jürgen
A1  - Pflugfelder, Annette
A1  - Meier, Friedegund
A1  - Busch, Christian
A1  - Eigentler, Thomas Kurt
A1  - Capper, David
A1  - Deimling, Andreas von
A1  - Mittelbronn, Michel Guy André
A1  - Perner, Sven
A1  - Ikenberg, Kristian
A1  - Hantschke, Markus
A1  - Büttner, Petra
A1  - Garbe, Claus
A1  - Weide, Benjamin
T1  - Survival according to BRAF-V600 tumor mutations : an analysis of 437 patients with primary melanoma
T2  - PLoS One
N2  - The prognostic impact of BRAF-V600 tumor mutations in stage I/II melanoma patients has not yet been analyzed in detail. We investigated primary tumors of 437 patients diagnosed between 1989 and 2006 by Sanger sequencing. Mutations were detected in 38.7% of patients and were associated with age, histological subtype as well as mitotic rate. The mutational rate was 36.7% in patients with disease-free course and 51.7% in those with subsequent distant metastasis (p = 0.031). No difference in overall survival (p = 0.119) but a trend for worse distant-metastasis-free survival (p = 0.061) was observed in BRAF mutant compared to BRAF wild-type patients. Independent prognostic factors for overall survival were tumor thickness, mitotic rate and ulceration. An interesting significant prognostic impact was observed in patients with tumor thickness of 1 mm or less, with the mutation present in 6 of 7 patients dying from melanoma. In conclusion, no significant survival differences were found according to BRAF-V600 tumor mutations in patients with primary melanoma but an increasing impact of the mutational status was observed in the subgroup of patients with tumor thickness of 1 mm or less. A potential role of the mutational status as a prognostic factor especially in this subgroup needs to be investigated in larger studies.
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/32795
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-327957
SN  - 1932-6203
N1  - Copyright: © 2014 Meckbach et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 9
IS  - (1):e86194
PB  - PLoS
CY  - Lawrence, Kan.
ER  -