TY  - JOUR
A1  - Güller, Saskia
A1  - Allwinn, Regina
A1  - Mousset, Sabine
A1  - Martin, Hans
A1  - Wieters, Imke
A1  - Herrmann, Eva
A1  - Serve, Hubert
A1  - Bickel, Markus
A1  - Bug, Gesine
T1  - Enhanced immune response after a second dose of an AS03-adjuvanted H1N1 influenza A vaccine in patients after hematopoietic stem cell transplantation
T2  - Biology of blood and marrow transplantation
N2  - Seroconversion rates following influenza vaccination in patients with hematologic malignancies after hematopoietic stem cell transplantation (HSCT) are known to be lower compared to healthy adults. The aim of our diagnostic study was to determine the rate of seroconversion after 1 or 2 doses of a novel split virion, inactivated, AS03-adjuvanted pandemic H1N1 influenza vaccine (A/California/7/2009) in HSCT recipients (ClinicalTrials.gov Identifier: NCT01017172). Blood samples were taken before and 21 days after a first dose and 21 days after a second dose of the vaccine. Antibody (AB) titers were determined by hemagglutination inhibition assay. Seroconversion was defined by either an AB titer of ≤1:10 before and ≥1:40 after or ≥1:10 before and ≥4-fold increase in AB titer 21 days after vaccination. Seventeen patients (14 allogeneic, 3 autologous HSCT) received 1 dose and 11 of these patients 2 doses of the vaccine. The rate of seroconversion was 41.2% (95% confidence interval [CI] 18.4-67.1) after the first and 81.8% (95% CI 48.2-97.7) after the second dose. Patients who failed to seroconvert after 1 dose of the vaccine were more likely to receive any immunosuppressive agent (P = .003), but time elapsed after or type of HSCT, age, sex, or chronic graft-versus-host disease was not different when compared to patients with seroconversion. In patients with hematologic malignancies after HSCT the rate of seroconversion after a first dose of an adjuvanted H1N1 influenza A vaccine was poor, but increased after a second dose.
KW  - HSCT
KW  - H1N1
KW  - Hemagglutination inhibition assay
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/44514
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-445145
SN  - 1523-6536
SN  - 1083-8791
N1  - Copyright © 2011 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. Under a Creative Commons license
VL  - 17
IS  - 10
SP  - 1546
EP  - 1550
PB  - Elsevier Health Sciences
CY  - [s. l.]
ER  -