TY  - JOUR
A1  - Horst, Klemens
A1  - Simon, Tim-Philipp
A1  - Pfeifer, Roman
A1  - Teuben, Michel Paul Johan
A1  - Almahmoud, Khalid
A1  - Qiao, Zhi
A1  - Aguiar Santos, Susana
A1  - Castelar Wembers, Carlos Emilio
A1  - Leonhardt, Steffen
A1  - Heussen, Nicole
A1  - Störmann, Philipp
A1  - Auner, Birgit
A1  - Relja, Borna
A1  - Marzi, Ingo
A1  - Haug, Alexander Tobias
A1  - Griensven, Martijn van
A1  - Kalbitz, Miriam
A1  - Huber-Lang, Markus
A1  - Tolba, René H.
A1  - Reiss, Lucy Kathleen
A1  - Uhlig, Stefan
A1  - Marx, Gernot
A1  - Pape, Hans-Christoph
A1  - Hildebrand, Frank
T1  - Characterization of blunt chest trauma in a long-term porcine model of severe multiple trauma
T2  - Scientific reports
N2  - Chest trauma has a significant relevance on outcome after severe trauma. Clinically, impaired lung function typically occurs within 72 hours after trauma. However, the underlying pathophysiological mechanisms are still not fully elucidated. Therefore, we aimed to establish an experimental long-term model to investigate physiological, morphologic and inflammatory changes, after severe trauma. Male pigs (sus scrofa) sustained severe trauma (including unilateral chest trauma, femur fracture, liver laceration and hemorrhagic shock). Additionally, non-injured animals served as sham controls. Chest trauma resulted in severe lung damage on both CT and histological analyses. Furthermore, severe inflammation with a systemic increase of IL-6 (p = 0.0305) and a local increase of IL-8 in BAL (p = 0.0009) was observed. The pO2/FiO2 ratio in trauma animals decreased over the observation period (p < 0.0001) but not in the sham group (p = 0.2967). Electrical Impedance Tomography (EIT) revealed differences between the traumatized and healthy lung (p < 0.0001). In conclusion, a clinically relevant, long-term model of blunt chest trauma with concomitant injuries has been developed. This reproducible model allows to examine local and systemic consequences of trauma and is valid for investigation of potential diagnostic or therapeutic options. In this context, EIT might represent a radiation-free method for bedside diagnostics.
KW  - Diagnostic markers
KW  - Experimental models of disease
KW  - Respiratory signs and symptoms
KW  - Translational research
KW  - Trauma
Y1  - 2016
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/46396
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-463961
SN  - 2045-2322
N1  - Rights and permissions: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
VL  - 6
IS  - Art. 39659
SP  - 1
EP  - 13
PB  - Macmillan Publishers Limited, part of Springer Nature
CY  - [London]
ER  -