TY  - JOUR
A1  - Nierhaus, Axel
A1  - Bloos, Frank
A1  - Wilson, Darius Cameron
A1  - Elke, Gunnar
A1  - Meybohm, Patrick
T1  - Predicting the requirement for renal replacement therapy in intensive care patients with sepsis
T2  - Critical care
N2  - Sepsis is one of the most frequent causes of acute kidney injury (AKI) in critically ill patients, with initial organ impairment often followed by dysfunction in other systems. Renal dysfunction may therefore represent one facet in the evolution towards multiple organ dysfunction syndrome (MODS) or, alternatively, may be indicative of system-wide endothelial damage caused by hyperinflammation and a positive fluid balance. Whilst numerous biomarkers have been investigated to predict renal replacement therapy (RRT) requirement, including NGAL, TIMP-2 and IGFBP-7, mid-regional proadrenomedullin (MR-proADM) may also be of interest due to its involvement in capillary leakage, endothelial dysfunction and the initial stages of multiple organ failure development. ...
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/46536
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-465366
SN  - 1466-609X
SN  - 1364-8535
N1  - Open Access: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
VL  - 22
IS  - 1, Art. 201
SP  - 1
EP  - 3
PB  - BioMed Central ; Springer
CY  - London ; Berlin ; Heidelberg
ER  -