TY  - JOUR
A1  - Hesler, Michelle
A1  - Aengenheister, Leonie
A1  - Ellinger, Bernhard
A1  - Drexel, Roland
A1  - Straskraba, Susanne
A1  - Jost, Carsten
A1  - Wagner, Sylvia
A1  - Meier, Florian
A1  - Briesen, Hagen von
A1  - Büchel, Claudia
A1  - Wick, Peter
A1  - Bürki-Thurnherr, Tina
A1  - Kohl, Yvonne
T1  - Multi-endpoint toxicological assessment of polystyrene nano- and microparticles in different biological models in vitro
T2  - Toxicology in vitro
N2  - Nanoplastics (NP) and microplastics (MP) accumulate in our environment as a consequence of the massive consumption of plastics. Huge knowledge-gaps exist regarding uptake and fate of plastic particles in micro- and nano-dimensions in humans as well as on their impact on human health.
This study investigated the transport and effects of 50 nm and 0.5 μm COOH-modified polystyrene (PS) particles, as representatives for NP and MP, in different biological models in vitro. Acute toxicity and potential translocation of the particles were studied at the human intestinal and placental barrier using advanced in vitro co-culture models. Furthermore, embryotoxicity and genotoxicity were investigated as highly sensitive endpoints.
Polystyrene was not acutely toxic in both sizes (nano- and microparticles). No transport across the intestinal and placental barrier but a cellular uptake and intracellular accumulation of PS nano- and microparticles were determined. The particles were identified as weak embryotoxic and non-genotoxic.
In contrast to single-organ studies, this multi-endpoint study is providing a data-set with the exact same type of particles to compare organ-specific outcomes. Our study clearly shows the need to investigate other types of plastics as well as towards long-term or chronic effects of plastic particles in different biological models in vitro.
KW  - Nano- and microplastics
KW  - Polystyrene
KW  - Multi-endpoint toxicity study
KW  - Intestinal barrier
KW  - Placental barrier
KW  - Embryotoxicity
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/50869
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-508696
SN  - 1879-3177
SN  - 0887-2333
N1  - © 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
VL  - 61
IS  - Art. 104610
SP  - 1
EP  - 15
PB  - Elsevier Science
CY  - Amsterdam [u. a.]
ER  -