TY  - JOUR
A1  - Cheedipudi, Sirisha
A1  - Genolet, Oriana
A1  - Dobreva, Gergana
T1  - Epigenetic inheritance of cell fates during embryonic development
T2  - Frontiers in genetics
N2  - During embryonic development a large number of widely differing and specialized cell types with identical genomes are generated from a single totipotent zygote. Tissue specific transcription factors cooperate with epigenetic modifiers to establish cellular identity in differentiated cells and epigenetic regulatory mechanisms contribute to the maintenance of distinct chromatin states and cell-type specific gene expression patterns, a phenomenon referred to as epigenetic memory. This is accomplished via the stable maintenance of various epigenetic marks through successive rounds of cell division. Preservation of DNA methylation patterns is a well-established mechanism of epigenetic memory, but more recently it has become clear that many other epigenetic modifications can also be maintained following DNA replication and cell division. In this review, we present an overview of the current knowledge regarding the role of histone lysine methylation in the establishment and maintenance of stable epigenetic states.
KW  - epigenetic memory
KW  - epigenetics
KW  - cell identity
KW  - inheritance
KW  - cell fate
KW  - histone modification
KW  - ES cells
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/52039
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-520395
SN  - 1664-8021
N1  - Copyright © 2014 Cheedipudi, Genolet and Dobreva. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
VL  - 5
IS  - Art. 19
SP  - 1
EP  - 7
PB  - Frontiers Media
CY  - Lausanne
ER  -