TY  - JOUR
A1  - Szakacs, Gergely
A1  - Abele, Rupert
T1  - An inventory of lysosomal ABC transporters
T2  - FEBS letters : for the rapid publication of short reports in biochemistry, biophysics, and molecular biology
N2  - ABC transporters fulfill diverse physiological functions in different cellularlocalizations ranging from the plasma membrane to intracellular membranouscompartments. Several ABC transporters have been spotted in the endolyso-somal system, which consists of endosomes, autophagosomes, lysosomes, andlysosome-related organelles. In this review, we present an overview of lysoso-mal ABC transporters including ABCA2, ABCA3, ABCA5, ABCB6,ABCB9, and ABCD4, discussing their trafficking routes, putative substrates,potential physiological functions, and associated diseases. In addition, weoffer a critical evaluation of the literature linking ABC transporters to lyso-somal drug sequestration, examining pitfalls associated with in vitro modelsof drug resistance.
KW  - ABC transporters
KW  - cholesterol
KW  - drug resistance
KW  - endolysosomal system
KW  - lipid
KW  - lysosomes
KW  - peptide transport
KW  - surfactant
KW  - trafficking
KW  - vitamin B12
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/61467
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-614671
SN  - 1873-3468
VL  - 594.2020
IS  - 23
SP  - 3965
EP  - 3985
PB  - Wiley
CY  - Chichester
ER  -