TY  - JOUR
A1  - Müller, Patricia
A1  - Sahlbach, Marlen
A1  - Gasper, Simone
A1  - Mayer, Günter
A1  - Müller, Jens
A1  - Pötzsch, Bernd
A1  - Heckel, Alexander
T1  - Controlling coagulation in blood with red light
T2  - Angewandte Chemie
N2  - Precise control of blood clotting and rapid reversal of anticoagulation are essential in many clinical situations. We were successful in modifying a thrombin-binding aptamer with a red-light photocleavable linker derived from Cy7 by Cu-catalyzed Click chemistry. We were able to show that we can successfully deactivate the modified aptamer with red light (660 nm) even in human blood—restoring the blood's natural coagulation capability.
KW  - aptamer
KW  - oligonucleotide
KW  - photocaging
KW  - phototherapeutic window
KW  - red light
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63939
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-639396
SN  - 1521-3773
N1  - This work was funded by the Deutsche Forschungsgemeinschaft (SFB 902, GRK 1986). Open access funding enabled and organized by Projekt DEAL.
VL  - 60
IS  - 41
SP  - 22441
EP  - 22446
PB  - Wiley-VCH
CY  - Weinheim
ER  -