TY  - JOUR
A1  - Sebode, Marcial
A1  - Weiler-Normann, Christina
A1  - Liwinski, Timur
A1  - Schramm, Christoph
T1  - Autoantibodies in autoimmune liver disease—clinical and diagnostic relevance
T2  - Frontiers in immunology
N2  - Testing for liver-related autoantibodies should be included in the workup of patients with hepatitis or cholestasis of unknown origin. Although most of these autoantibodies are not disease specific, their determination is a prerequisite to diagnose autoimmune hepatitis (AIH) and primary biliary cholangitis (PBC), and they are components of the diagnostic scoring system in these diseases. In primary sclerosing cholangitis (PSC), on the other hand, autoantibodies are frequently present but play a minor role in establishing the diagnosis. In PSC, however, data on antibodies suggest a link between disease pathogenesis and the intestinal microbiota. This review will focus on practical aspects of antibody testing in the three major autoimmune liver diseases AIH, PBC, and PSC.
KW  - autoimmune hepatitis
KW  - primary biliary cholangitis
KW  - primary sclerosing cholangitis
KW  - antinuclear antibodies
KW  - smooth muscle antibodies
KW  - antimitochondrial antibodies
KW  - soluble liver antigen/liver–pancreas antigen
KW  - serology
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/52582
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-525825
SN  - 1664-3224
N1  - Copyright: © 2018 Sebode, Weiler-Normann, Liwinski and Schramm. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
VL  - 9
IS  - Art. 609
SP  - 1
EP  - 12
PB  - Frontiers Media
CY  - Lausanne
ER  -