TY  - JOUR
A1  - Hirvonen, Jonni
A1  - Wibral, Michael
A1  - Palva, Jaakko Matias
A1  - Singer, Wolf
A1  - Uhlhaas, Peter J.
A1  - Palva, Satu
T1  - Whole-brain source-reconstructed MEG-data reveal reduced longrange
synchronization in chronic schizophrenia
T2  - eNeuro
N2  - Current theories of schizophrenia (ScZ) posit that the symptoms and cognitive dysfunctions arise from a dysconnection syndrome. However, studies that have examined this hypothesis with physiological data at realistic time scales are so far scarce. The current study employed a state-of-the-art approach using Magnetoencephalography (MEG) to test alterations in large-scale phase synchronization in a sample of n = 16 chronic ScZ patients, 10 males and n = 19 healthy participants, 10 males, during a perceptual closure task. We identified large-scale networks from source reconstructed MEG data using data-driven analyses of neuronal synchronization. Oscillation amplitudes and interareal phase-synchronization in the 3–120 Hz frequency range were estimated for 400 cortical parcels and correlated with clinical symptoms and neuropsychological scores. ScZ patients were characterized by a reduction in γ-band (30–120 Hz) oscillation amplitudes that was accompanied by a pronounced deficit in large-scale synchronization at γ-band frequencies. Synchronization was reduced within visual regions as well as between visual and frontal cortex and the reduction of synchronization correlated with elevated clinical disorganization. Accordingly, these data highlight that ScZ is associated with a profound disruption of transient synchronization, providing critical support for the notion that core aspect of the pathophysiology arises from an impairment in coordination of distributed neural activity.
KW  - MEG
KW  - oscillation
KW  - perception
KW  - schizophrenia
KW  - synchronization
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/45082
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-450821
SN  - 2373-2822
N1  - Copyright & Usage: Copyright © 2017 Hirvonen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
VL  - 4
IS  - 5, e0338-17.2017
SP  - 1
EP  - 14
PB  - Society for Neuroscience
CY  - Washington, DC
ER  -