TY  - JOUR
A1  - Bernhardt, Dominik
A1  - Müller, Matthias
A1  - Reichert, Andreas
A1  - Osiewacz, Heinz D.
T1  - Simultaneous impairment of mitochondrial fission and fusion reduces mitophagy and shortens replicative lifespan
T2  - Scientific reports, 5.2015, 7885
N2  - Aging of biological systems is accompanied by degeneration of mitochondrial functions. Different pathways are active to counteract the processes which lead to mitochondrial dysfunction. Mitochondrial dynamics, the fission and fusion of mitochondria, is one of these quality control pathways. Mitophagy, the controlled degradation of mitochondria, is another one. Here we show that these pathways are linked. A double deletion mutant of Saccharomyces cerevisiae in which two essential components of the fission and fusion machinery, Dnm1 and Mgm1, are simultaneously ablated, contain wild-type like filamentous mitochondria, but are characterized by impaired respiration, an increased sensitivity to different stressors, increased mitochondrial protein carbonylation, and a decrease in mitophagy and replicative lifespan. These data show that a balanced mitochondrial dynamics and not a filamentous mitochondrial morphotype per se is the key for a long lifespan and demonstrate a cross-talk between two different mitochondrial quality control pathways.
Y1  - 2015
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/39385
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-393854
SN  - 2045-2322
N1  - This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http:// creativecommons.org/licenses/by-nc-nd/4.0/
VL  - 5
IS  - 7885
SP  - 1
EP  - 9
PB  - Nature Publishing Group
CY  - London
ER  -