TY  - JOUR
A1  - Candlish, Michael
A1  - Hefendehl, Jasmin Kim
T1  - Microglia phenotypes converge in aging and neurodegenerative disease
T2  - Frontiers in neurology
N2  - Microglia, the primary immune cells of the central nervous system, hold a multitude of tasks in order to ensure brain homeostasis and are one of the best predictors of biological age on a cellular level. We and others have shown that these long-lived cells undergo an aging process that impedes their ability to perform some of the most vital homeostatic functions such as immune surveillance, acute injury response, and clearance of debris. Microglia have been described as gradually transitioning from a homeostatic state to an activated state in response to various insults, as well as aging. However, microglia show diverse responses to presented stimuli in the form of acute injury or chronic disease. This complexity is potentially further compounded by the distinct alterations that globally occur in the aging process. In this review, we discuss factors that may contribute to microglial aging, as well as transcriptional microglia alterations that occur in old age. We then compare these distinct phenotypic changes with microglial phenotype in neurodegenerative disease.
KW  - microglia
KW  - aging
KW  - neurodegeneration
KW  - alzheimer’s disease
KW  - senescence
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/61142
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-611426
SN  - 1664-2295
VL  - 12
IS  - art. 660720
SP  - 1
EP  - 7
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  -