TY  - JOUR
A1  - Syed, Shahzad Nawaz
A1  - Brüne, Bernhard
T1  - Exosomal and non-exosomal microRNAs: new kids on the block for cancer therapy
T2  - International journal of molecular sciences
N2  - MicroRNAs have been projected as promising tools for diagnostic and prognostic purposes in cancer. More recently, they have been highlighted as RNA therapeutic targets for cancer therapy. Though miRs perform a generic function of post-transcriptional gene regulation, their utility in RNA therapeutics mostly relies on their biochemical nature and their assembly with other macromolecules. Release of extracellular miRs is broadly categorized into two different compositions, namely exosomal (extracellular vesicles) and non-exosomal. This nature of miRs not only affects the uptake into target cells but also poses a challenge and opportunity for RNA therapeutics in cancer. By virtue of their ability to act as mediators of intercellular communication in the tumor microenvironment, extracellular miRs perform both, depending upon the target cell and target landscape, pro- and anti-tumor functions. Tumor-derived miRs mostly perform pro-tumor functions, whereas host cell- or stroma-derived miRs are involved in anti-tumor activities. This review deals with the recent understanding of exosomal and non-exosomal miRs in the tumor microenvironment, as a tool for pro- and anti-tumor activity and prospective exploit options for cancer therapy.
KW  - microRNA
KW  - cancer
KW  - macrophage
KW  - breast cancer
KW  - exosome
KW  - RNA therapeutics
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/80411
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-804116
SN  - 1422-0067
N1  - his study is supported by Deutsche Forschungsgemeinschaft (SFB 1039 TP B04; FOR 2438, TP 7, and BR999 25-1).
VL  - 23
IS  - 9, art.  4493
SP  - 1
EP  - 21
PB  - Molecular Diversity Preservation International
CY  - Basel
ER  -