TY  - JOUR
A1  - Stürner, Tomke
A1  - Castro, André Ferreira
A1  - Philipps, Maren
A1  - Cuntz, Hermann
A1  - Tavosanis, Gaia
T1  - The branching code: A model of actin-driven dendrite arborization
T2  - Cell Reports
N2  - The cytoskeleton is crucial for defining neuronal-type-specific dendrite morphologies. To explore how the complex interplay of actin-modulatory proteins (AMPs) can define neuronal types in vivo, we focused on the class III dendritic arborization (c3da) neuron of Drosophila larvae. Using computational modeling, we reveal that the main branches (MBs) of c3da neurons follow general models based on optimal wiring principles, while the actin-enriched short terminal branches (STBs) require an additional growth program. To clarify the cellular mechanisms that define this second step, we thus concentrated on STBs for an in-depth quantitative description of dendrite morphology and dynamics. Applying these methods systematically to mutants of six known and novel AMPs, we revealed the complementary roles of these individual AMPs in defining STB properties. Our data suggest that diverse dendrite arbors result from a combination of optimal-wiring-related growth and individualized growth programs that are neuron-type specific.
KW  - actin
KW  - actin-modulatory proteins
KW  - computational modeling
KW  - neuron
KW  - dendrite
KW  - Drosophila
KW  - dendritic arborization neurons
KW  - optimal wiring
KW  - morphometrics
KW  - time-lapse imaging
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/78315
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-783155
SN  - 2211-1247
VL  - 39
IS  - 4, art. 110746
PB  - Elsevier
CY  - Amsterdam
ER  -