TY  - JOUR
A1  - Wenzel, Mike
A1  - Siron, Nicolas
A1  - Collà Ruvolo, Claudia
A1  - Nocera, Luigi
A1  - Würnschimmel, Christoph
A1  - Tian, Zhe
A1  - Shariat, Shahrokh F.
A1  - Saad, Fred
A1  - Briganti, Alberto
A1  - Tilki, Derya
A1  - Banek, Séverine
A1  - Kluth, Luis
A1  - Roos, Frederik
A1  - Chun, Felix
A1  - Karakiewicz, Pierre I.
T1  - Temporal trends, tumor characteristics and stage-specific survival in penile non-squamous cell carcinoma vs. squamous cell carcinoma
T2  - Cancer causes & control
N2  - Purpose: To compare Cancer-specific mortality (CSM) in patients with Squamous cell carcinoma (SCC) vs. non-SCC penile cancer, since survival outcomes may differ between histological subtypes. Methods: Within the Surveillance, Epidemiology and End Results database (2004–2016), penile cancer patients of all stages were identified. Temporal trend analyses, cumulative incidence and Kaplan–Meier plots, multivariable Cox regression and Fine and Gray competing-risks regression analyses tested for CSM differences between non-SCC vs. SCC penile cancer patients. Results: Of 4,120 eligible penile cancer patients, 123 (3%) harbored non-SCC vs. 4,027 (97%) SCC. Of all non-SCC patients, 51 (41%) harbored melanomas, 42 (34%) basal cell carcinomas, 10 (8%) adenocarcinomas, eight (6.5%) skin appendage malignancies, six (5%) epithelial cell neoplasms, two (1.5%) neuroendocrine tumors, two (1.5%) lymphomas, two (1.5%) sarcomas. Stage at presentation differed between non-SCC vs. SCC. In temporal trend analyses, non-SCC diagnoses neither decreased nor increased over time (p > 0.05). After stratification according to localized, locally advanced, and metastatic stage, no CSM differences were observed between non-SCC vs. SCC, with 5-year survival rates of 11 vs 11% (p = 0.9) for localized, 33 vs. 37% (p = 0.4) for locally advanced, and 1-year survival rates of 37 vs. 53% (p = 0.9) for metastatic penile cancer, respectively. After propensity score matching for patient and tumor characteristics and additional multivariable adjustment, no CSM differences between non-SCC vs. SCC were observed. Conclusion: Non-SCC penile cancer is rare. Although exceptions exist, on average, non-SCC penile cancer has comparable CSM as SCC penile cancer patients, after stratification for localized, locally invasive, and metastatic disease.
KW  - Penile cancer
KW  - Variant histology
KW  - Squamous cell carcinoma
KW  - CSM
KW  - Cancer-specific mortality
KW  - SCC
KW  - Adenocarcinoma
KW  - Melanoma
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63562
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-635624
SN  - 1573-7225
N1  - Open Access funding enabled and organized by Projekt DEAL.
N1  - Early View: Online Version before inclusion in an issue
VL  - 2021
IS  - online version before inclusion in an issue
PB  - Springer Science + Business Media B.V.
CY  - Dordrecht [u.a.]
ER  -