TY  - JOUR
A1  - Lewis, Christopher Murphy
A1  - Jianguang, Ni
A1  - Wunderle, Thomas
A1  - Jendritza, Patrick
A1  - Lazar, Andreea
A1  - Diester, Ilka
A1  - Fries, Pascal
T1  - Cortical resonance selects coherent input
T2  - Cell Reports
N2  - Synchronization has been implicated in neuronal communication, but causal evidence remains indirect. We use optogenetics to generate depolarizing currents in pyramidal neurons of the cat visual cortex, emulating excitatory synaptic inputs under precise temporal control, while measuring spike output. The cortex transforms constant excitation into strong gamma-band synchronization, revealing the well-known cortical resonance. Increasing excitation with ramps increases the strength and frequency of synchronization. Slow, symmetric excitation profiles reveal hysteresis of power and frequency. White-noise input sequences enable causal analysis of network transmission, establishing that the cortical gamma-band resonance preferentially transmits coherent input components. Models composed of recurrently coupled excitatory and inhibitory units uncover a crucial role of feedback inhibition and suggest that hysteresis can arise through spike-frequency adaptation. The presented approach provides a powerful means to investigate the resonance properties of local circuits and probe how these properties transform input and shape transmission.
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/73329
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-733299
SN  - 2211-1247
VL  - 35
IS  - 109083
PB  - Cell Press
CY  - Maryland Heights, MO
ER  -