TY  - JOUR
A1  - Schuhmacher, Bianca
A1  - Rengstl, Benjamin
A1  - Döring, Claudia
A1  - Bein, Julia
A1  - Newrzela, Sebastian
A1  - Brunnberg, Uta
A1  - Kvasnicka, Hans Michael
A1  - Vornanen, Martine
A1  - Küppers, Ralf
A1  - Hansmann, Martin-Leo
A1  - Hartmann, Sylvia
T1  - A strong host response and lack of MYC expression are characteristic for diffuse large B cell lymphoma transformed from nodular lymphocyte predominant Hodgkin lymphoma
T2  - Oncotarget
N2  - Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is an indolent lymphoma, but can transform into diffuse large B cell lymphoma (DLBCL), showing a more aggressive clinical behavior. Little is known about these cases on the molecular level. Therefore, the aim of the present study was to characterize DLBCL transformed from NLPHL (LP-DLBCL) by gene expression profiling (GEP). GEP revealed an inflammatory signature pinpointing to a specific host response. In a coculture model resembling this host response, DEV tumor cells showed an impaired growth behavior. Mechanisms involved in the reduced tumor cell proliferation included a downregulation of MYC and its target genes. Lack of MYC expression was also confirmed in 12/16 LP-DLBCL by immunohistochemistry. Furthermore, CD274/PD-L1 was upregulated in DEV tumor cells after coculture with T cells or monocytes and its expression was validated in 12/19 cases of LP-DLBCL. Thereby, our data provide new insights into the pathogenesis of LP-DLBCL and an explanation for the relatively low tumor cell content. Moreover, the findings suggest that treatment of these patients with immune checkpoint inhibitors may enhance an already ongoing host response in these patients.
KW  - nodular lymphocyte predominant Hodgkin lymphoma
KW  - diffuse large B cell lymphoma
KW  - T cell/histiocyte rich large B cell lymphoma
KW  - host response
KW  - gene expression profiling
Y1  - 2016
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/45834
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-458348
SN  - 1949-2553
N1  - All site content, except where otherwise noted, is licensed under a Creative Commons Attribution 3.0 License.
VL  - 7
IS  - 44
SP  - 72197
EP  - 72210
PB  - Impact Journals LLC
CY  - [S.l.]
ER  -