TY  - JOUR
A1  - Schäfer, Liliana
T1  - Complexity of danger: the diverse nature of damage-associated molecular patterns
T2  - Journal of biological chemistry
N2  - In reply to internal or external danger stimuli, the body orchestrates an inflammatory response. The endogenous triggers of this process are the damage-associated molecular patterns (DAMPs). DAMPs represent a heterogeneous group of molecules that draw their origin either from inside the various compartments of the cell or from the extracellular space. Following interaction with pattern recognition receptors in cross-talk with various non-immune receptors, DAMPs determine the downstream signaling outcome of septic and aseptic inflammatory responses. In this review, the diverse nature, structural characteristics, and signaling pathways elicited by DAMPs will be critically evaluated.
KW  - ATP
KW  - Autophagy
KW  - Biglycan
KW  - Decorin
KW  - Heat Shock Protein (HSP)
KW  - Heparan Sulfate
KW  - Hyaluronan
KW  - Inflammasome
KW  - Necrosis (Necrotic Death)
KW  - Small Leucine-rich Proteoglycan (SLRP)
KW  - Toll-like Receptor (TLR)
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/76970
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-769702
SN  - 0021-9258
VL  - 289
IS  - 51
SP  - 35237
EP  - 35245
PB  - American Society for Biochemistry and Molecular Biology Publications
CY  - Bethesda, Md
ER  -