TY  - JOUR
A1  - Ortiz, Cristina
A1  - Schierwagen, Robert
A1  - Schäfer, Liliana
A1  - Klein, Sabine
A1  - Trepat, Xavier
A1  - Trebicka, Jonel
T1  - Extracellular matrix remodeling in chronic liver disease
T2  - Current tissue microenvironment reports
N2  - Purpose of the Review: This review aims to summarize the current knowledge of the extracellular matrix remodeling during hepatic fibrosis. We discuss the diverse interactions of the extracellular matrix with hepatic cells and the surrounding matrix in liver fibrosis, with the focus on the molecular pathways and the mechanisms that regulate extracellular matrix remodeling.
Recent Findings: The extracellular matrix not only provides structure and support for the cells, but also controls cell behavior by providing adhesion signals and by acting as a reservoir of growth factors and cytokines.
Summary: Hepatic fibrosis is characterized by an excessive accumulation of extracellular matrix. During fibrogenesis, the natural remodeling process of the extracellular matrix varies, resulting in the excessive accumulation of its components, mainly collagens. Signals released by the extracellular matrix induce the activation of hepatic stellate cells, which are the major source of extracellular matrix and most abundant myofibroblasts in the liver.
KW  - Liver fibrosis
KW  - Extracellular matrix
KW  - Hepatic stellate cell
KW  - Collagen
KW  - Metalloproteinases
KW  - TGF-β1
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/75715
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-757153
SN  - 2662-4079
N1  - Open Access funding enabled and organized by Projekt DEAL.
VL  - 2
IS  - 3
SP  - 41
EP  - 52
PB  - Springer International Publishing
CY  - Cham
ER  -