TY  - JOUR
A1  - Heil, Matthias
A1  - Eitenmüller, Inka Kathrin
A1  - Schmitz-Rixen, Thomas
A1  - Schaper, Wolfgang
T1  - Arteriogenesis versus angiogenesis: similarities and differences
T2  - Journal of cellular and molecular medicine
N2  - Cardiovascular diseases account for more than half of total mortality before the age of 75 in industrialized countries. To develop therapies promoting the compensatory growth of blood vessels could be superior to palliative surgical surgical interventions. Therefore, much effort has been put into investigating underlying mechanisms. Depending on the initial trigger, growth of blood vessels in adult organisms proceeds via two major processes, angiogenesis and arteriogenesis. While angiogenesis is induced by hypoxia and results in new capillaries, arteriogenesis is induced by physical forces, most importantly fluid shear stress. Consequently, chronically elevated fluid shear stress was found to be the strongest trigger under experimental conditions. Arteriogenesis describes the remodelling of pre-existing arterio-arteriolar anastomoses to completely developed and functional arteries. In both growth processes, enlargement of vascular wall structures was proposed to be covered by proliferation of existing wall cells. Recently, increasing evidence emerges, implicating a pivotal role for circulating cells, above all blood monocytes, in vascular growth processes. Since it has been shown that monocytes/macrophage release a cocktail of chemokines, growth factors and proteases involved in vascular growth, their contribution seems to be of a paracrine fashion. A similar role is currently discussed for various populations of bone-marrow derived stem cells and endothelial progenitors. In contrast, the initial hypothesis that these cells -after undergoing a (trans-)differentiation- contribute by a structural integration into the growing vessel wall, is increasingly challenged.
KW  - arteriogenesis
KW  - angiogenesis
KW  - monocytes
KW  - bone-marrow
KW  - fluid shear stress
Y1  - 2006
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/27960
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-279609
UR  - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3933101/
SN  - 1582-4934
SN  - 1582-1838
N1  - This is an Open Access article under the terms of the Creative Commons Attribution Non Commercial License http://creativecommons.org/licenses/by-nc/3.0/ which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
VL  - 10
IS  - 1
SP  - 45
EP  - 55
PB  - Wiley-Blackwell
CY  - Hoboken, NJ
ER  -