TY  - JOUR
A1  - Fox, Brandon M.
A1  - Janssen, Andrew
A1  - Estevez-Ordonez, Dagoberto
A1  - Geßler, Florian
A1  - Vicario, Nunzio
A1  - Chagoya, Gustavo
A1  - Elsayed, Galal
A1  - Sotoudeh, Houman
A1  - Stetler, William
A1  - Friedman, Gregory K.
A1  - Bernstock, Joshua D.
T1  - SUMOylation in glioblastoma : a novel therapeutic target
T2  - International journal of molecular sciences
N2  - Protein SUMOylation is a dynamic post-translational modification which is involved in a diverse set of physiologic processes throughout the cell. Of note, SUMOylation also plays a role in the pathobiology of a myriad of cancers, one of which is glioblastoma (GBM). Accordingly, herein, we review core aspects of SUMOylation as it relates to GBM and in so doing highlight putative methods/modalities capable of therapeutically engaging the pathway for treatment of this deadly neoplasm.
KW  - glioblastoma (GBM)
KW  - SUMOylation
KW  - SUMO1-3
KW  - post-translational modifications (PTMs)
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/50749
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-507492
SN  - 1422-0067
SN  - 1661-6596
N1  - This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
VL  - 20
IS  - 8, Art. 1853
SP  - 1
EP  - 13
PB  - Molecular Diversity Preservation International
CY  - Basel
ER  -