TY  - JOUR
A1  - Epping, Lisa
A1  - Miesbach, Wolfgang
A1  - Nickles, Katrin
A1  - Eickholz, Peter
T1  - Is gingival bleeding a symptom of type 2 and 3 von Willebrand disease?
T2  - PLoS one
N2  - Background: Von Willebrand disease (VWD) is the most common inherent bleeding disorder. Gingival bleeding is a frequently reported symptom of VWD. However, gingival bleeding is also a leading symptom of plaque-induced gingivitis and untreated periodontal disease. In type 1 VWD gingival bleeding was not increased compared to controls. Thus, this study evaluated whether type 2 and 3 VWD determines an increased susceptibility to gingival bleeding in response to the oral biofilm.
Methods: Twenty-four cases and 24 controls matched for age, sex, periodontal diagnosis, number of teeth and smoking were examined hematologically (VWF antigen, VWF activity, factor VIII activity) and periodontally (Gingival Bleeding Index [GBI]), bleeding on probing [BOP], Plaque Control Record [PCR], periodontal inflamed surface area [PISA], vertical probing attachment level).
Results: BOP (VWD: 14.5±10.1%; controls: 12.3±5.3%; p = 0.542) and GBI (VWD: 10.5±9.9%; controls: 8.8±4.8%; p = 0.852) were similar for VWD and controls. Multiple regressions identified female sex, HbA1c, PCR and PISA to be associated with BOP. HbA1c and PCR were associated with GBI. Number of remaining teeth was negatively correlated with BOP and GBI.
Conclusion: Type 2 and 3 VWD are not associated with a more pronounced inflammatory response to the oral biofilm in terms of BOP and GBI.
KW  - Hemorrhage
KW  - Dentition
KW  - Periodontal diseases
KW  - Periodontitis
KW  - Hematology
KW  - Inflammatory diseases
KW  - Smoking habits
KW  - Teeth
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/43114
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-431141
SN  - 1932-6203
N1  - Copyright: © 2018 Epping et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
VL  - 13
IS  - (1): e0191291
SP  - 1
EP  - 11
PB  - PLoS
CY  - Lawrence, Kan.
ER  -