TY  - JOUR
A1  - Oo, James A.
A1  - Brandes, Ralf
A1  - Leisegang, Matthias
T1  - Long non-coding RNAs: novel regulators of cellular physiology and function
T2  - Pflügers Archiv : European journal of physiology
N2  - Long non-coding RNAs were once considered as “junk” RNA produced by aberrant DNA transcription. They are now understood to play central roles in diverse cellular processes from proliferation and migration to differentiation, senescence and DNA damage control. LncRNAs are classed as transcripts longer than 200 nucleotides that do not encode a peptide. They are relevant to many physiological and pathophysiological processes through their control of fundamental molecular functions. This review summarises the recent progress in lncRNA research and highlights the far-reaching physiological relevance of lncRNAs. The main areas of lncRNA research encompassing their characterisation, classification and mechanisms of action will be discussed. In particular, the regulation of gene expression and chromatin landscape through lncRNA control of proteins, DNA and other RNAs will be introduced. This will be exemplified with a selected number of lncRNAs that have been described in numerous physiological contexts and that should be largely representative of the tens-of-thousands of mammalian lncRNAs. To some extent, these lncRNAs have inspired the current thinking on the central dogmas of epigenetics, RNA and DNA mechanisms.
KW  - Long non-coding RNA
KW  - Physiology
KW  - Pathophysiology
KW  - ncRNA
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/69574
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-695740
SN  - 1432-2013
N1  - Open Access funding enabled and organized by Projekt DEAL. This work was supported by the Goethe University Frankfurt am Main, the German Centre for Cardiovascular Research (DZHK, PostDoc Startup Grant, 81X3200107) and the DFG Transregio TRR267 (TPA04&TPA06).
VL  - 474
IS  - 2
SP  - 191
EP  - 204
PB  - Springer
CY  - Berlin ; Heidelberg
ER  -