TY  - JOUR
A1  - Rakauskas, Arnas
A1  - Marra, Giancarlo
A1  - Heidegger, Isabel
A1  - Kasivisvanathan, Veeru
A1  - Kretschmer, Alexander
A1  - Zattoni, Fabio
A1  - Preißer, Felix Martin
A1  - Tilki, Derya
A1  - Tsaur, Igor
A1  - Bergh, Roderick van den
A1  - Kesch, Claudia
A1  - Ceci, Francesco
A1  - Fankhauser, Christian D.
A1  - Gandaglia, Giorgio
A1  - Valerio, Massimo
T1  - Focal therapy for prostate cancer: complications and their treatment
T2  - Frontiers in Surgery
N2  - Focal therapy is a modern alternative to selectively treat a specific part of the prostate harboring clinically significant disease while preserving the rest of the gland. The aim of this therapeutic approach is to retain the oncological benefit of active treatment and to minimize the side-effects of common radical treatments. The oncological effectiveness of focal therapy is yet to be proven in long-term robust trials. In contrast, the toxicity profile is well-established in randomized controlled trials and multiple robust prospective cohort studies. This narrative review summarizes the relevant evidence on complications and their management after focal therapy. When compared to whole gland treatments, focal therapy provides a substantial benefit in terms of adverse events reduction and preservation of genito-urinary function. The most common complications occur in the peri-operative period. Urinary tract infection and acute urinary retention can occur in up to 17% of patients, while dysuria and haematuria are more common. Urinary incontinence following focal therapy is very rare (0–5%), and the vast majority of patients recover in few weeks. Erectile dysfunction can occur after focal therapy in 0–46%: the baseline function and the ablation template are the most important factors predicting post-operative erectile dysfunction. Focal therapy in the salvage setting after external beam radiotherapy has a significantly higher rate of complications. Up to one man in 10 will present a severe complication.
KW  - prostate cancer
KW  - focal therapy
KW  - HIFU
KW  - cryotherapy
KW  - photodynamic therapy
KW  - complications
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62039
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-620397
SN  - 2296-875X
VL  - 8.2021
IS  - art. 696242
SP  - 1
EP  - 6
PB  - Frontiers Media
CY  - Lausanne
ER  -