TY  - JOUR
A1  - Wesche, Frank
A1  - He, Yue
A1  - Bode, Helge Björn
T1  - Solid-phase enrichment and analysis of electrophilic natural products
T2  - Beilstein journal of organic chemistry
N2  - In search for new natural products, which may lead to the development of new drugs for all kind of applications, novel methods are needed. Here we describe the identification of electrophilic natural products in crude extracts via their reactivity against azide as a nucleophile followed by their subsequent enrichment using a cleavable azide-reactive resin (CARR). Using this approach, natural products carrying epoxides and α,β-unsaturated enones as well as several unknown compounds were identified in crude extracts from entomopathogenic Photorhabdus bacteria.
KW  - azides
KW  - click chemistry
KW  - enrichment
KW  - electrophilic natural products
KW  - epoxides
KW  - glidobactin
KW  - Photorhabdus
KW  - stilbenes
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/44236
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-442365
SN  - 1860-5397
N1  - © 2017 Wesche et al.; licensee Beilstein-Institut. This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)
VL  - 13
IS  - 1
SP  - 405
EP  - 409
PB  - Beilstein-Institut zur Förderung der Chemischen Wissenschaften
CY  - Frankfurt, Main
ER  -