TY  - JOUR
A1  - Harks, Inga
A1  - Koch, Raphael
A1  - Eickholz, Peter
A1  - Hoffmann, Thomas
A1  - Kim, Ti-Sun
A1  - Kocher, Thomas
A1  - Meyle, Jörg
A1  - Kaner, Doğan
A1  - Schlagenhauf, Ulrich
A1  - Doering, Stephan
A1  - Holtfreter, Birte
A1  - Gravemeier, Martina
A1  - Harmsen, Dag
A1  - Ehmke, Benjamin
T1  - Is progression of periodontitis relevantly influenced by systemic antibiotics? : a clinical randomized trial
T2  - Journal of clinical periodontology
N2  - Aim: We investigated the long-term impact of adjunctive systemic antibiotics on periodontal disease progression. Periodontal therapy is frequently supplemented by systemic antibiotics, although its impact on the course of disease is still unclear.
Material & Methods: This prospective, randomized, double-blind, placebo-controlled multi-centre trial comprising patients suffering from moderate to severe periodontitis evaluated the impact of rational adjunctive use of systemic amoxicillin 500 mg plus metronidazole 400 mg (3x/day, 7 days) on attachment loss. The primary outcome was the percentage of sites showing further attachment loss (PSAL) ≥1.3 mm after the 27.5 months observation period. Standardized therapy comprised mechanical debridement in conjunction with antibiotics or placebo administration, and maintenance therapy at 3 months intervals.
Results: From 506 participating patients, 406 were included in the intention to treat analysis. Median PSAL observed in placebo group was 7.8% compared to 5.3% in antibiotics group (Q25 4.7%/Q75 14.1%; Q25 3.1%/Q75 9.9%; p < 0.001 respectively).
Conclusions: Both treatments were effective in preventing disease progression. Compared to placebo, the prescription of empiric adjunctive systemic antibiotics showed a small absolute, although statistically significant, additional reduction in further attachment loss. Therapists should consider the patient's overall risk for periodontal disease when deciding for or against adjunctive antibiotics prescription.
KW  - amoxicillin/metronidazole
KW  - attachment loss
KW  - clinical relevance
KW  - debridement
KW  - outcome parameter
KW  - periodontitis
KW  - randomised controlled trial
KW  - systemic antibiotics
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/42801
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-428010
SN  - 1600-051X
SN  - 0303-6979
N1  - © 2015 The Authors. Journal of Clinical Periodontology Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
VL  - 42
IS  - 9
SP  - 853
EP  - 842
PB  - Wiley-Blackwell
CY  - Oxford [u. a.]
ER  -