TY  - JOUR
A1  - Teschke, Rolf
A1  - Bahre, Ruediger
T1  - Severe hepatotoxicity by Indian Ayurvedic herbal products: A structured causality assessment
T2  - Annals of Hepatology
N2  - The case of a 64 year old female patient is presented who has treated herself for 9 months with various Indian Ayurvedic herbal products for her vitiligo and experienced a causally related severe hepatotoxicity (ALT, 601 U/L; AST, 663 U/L; Bilirubin, 5.0 mg/dL). After discontinuation, a rapid improvement was observed. Causality assessment with the updated CIOMS (Council for International Organizations of Medical Sciences) scale showed a probable causality (+8 points) for Bakuchi tablets containing extracts from Psoralea corylifolia leaves with psoralens as ingredients, as the primary candidate causing the hepatotoxic reaction. The degree of probability was lower with +6 points for other used herbs: Khadin tablets containing extracts from Acacia catechu leaves; Brahmi tablets containing Eclipta alba or Bacopa monnieri; and Usheer tea prepared from Vetivexia zizaniodis. The case is the first report of Indian Ayurvedic herbal products being potentially hepatotoxic in analogy to some other herbs.
KW  - Ayurvedic herbal products
KW  - Hepatotoxicity
KW  - Causality assessment.
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/76442
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-764426
SN  - 1665-2681
VL  - 8
IS  - 3
SP  - 258
EP  - 266
PB  - Mexican Association of Hepatology
CY  - México
ER  -