TY  - JOUR
A1  - Iozzo, Renato V.
A1  - Schäfer, Liliana
T1  - Proteoglycan form and function: a comprehensive nomenclature of proteoglycans
T2  - Matrix Biology
N2  - We provide a comprehensive classification of the proteoglycan gene families and respective protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular location, overall gene/protein homology, and the utilization of specific protein modules within their respective protein cores. These three signatures were utilized to design four major classes of proteoglycans with distinct forms and functions: the intracellular, cell-surface, pericellular and extracellular proteoglycans. The proposed nomenclature encompasses forty-three distinct proteoglycan-encoding genes and many alternatively-spliced variants. The biological functions of these four proteoglycan families are critically assessed in development, cancer and angiogenesis, and in various acquired and genetic diseases where their expression is aberrant.
Y1  - 2015
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/53433
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-534334
SN  - 0945-053X
N1  - This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
VL  - 42
SP  - 11
EP  - 55
PB  - Elsevier
CY  - Amsterdam [u.a.]
ER  -